ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2014
Comprehensive transcriptome profiling and functional analysis of the frog (Bombina maxima) immune system.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
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- A pore-forming protein drives macropinocytosis to facilitate toad water maintaining.Communications biology · 2022Article
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- The Immune System and the Antiviral Responses in Chinese Giant Salamander,Frontiers in immunology · 2021Review
- A cellular endolysosome-modulating pore-forming protein from a toad is negatively regulated by its paralog under oxidizing conditions.The Journal of biological chemistry · 2020Article
- Comparative analysis of diverse toxins from a new pharmaceutical centipede,Zoological research · 2020Article
- Proteotranscriptomic Analysis and Discovery of the Profile and Diversity of Toxin-like Proteins in Centipede.Molecular & cellular proteomics : MCP · 2018Article
- Deep sequencing analysis of toadThe journal of venomous animals and toxins including tropical diseases · 2018Article
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- Frog Skin Innate Immune Defences: Sensing and Surviving Pathogens.Frontiers in immunology · 2018Review
- A practical guide to buildPeerJ · 2017Article
- Research proceedings on amphibian model organisms.Dong wu xue yan jiu = Zoological research · 2016Review
- Pore-forming toxins: ancient, but never really out of fashion.Nature reviews. Microbiology · 2016Review
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- Reduced immune function predicts disease susceptibility in frogs infected with a deadly fungal pathogen.Conservation physiology · 2016Article
- Why do we study animal toxins?Dong wu xue yan jiu = Zoological research · 2015Review
- Constraint and adaptation in newt toll-like receptor genes.Genome biology and evolution · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amphibians occupy a key phylogenetic position in vertebrates and evolution of the immune system. But, the resources of its transcriptome or genome are still little now. Bombina maxima possess strong ability to survival in very harsh environment with a more mature immune system. We obtained a comprehensive transcriptome by RNA-sequencing technology. 14.3% of transcripts were identified to be skin-specific genes, most of which were not isolated from skin secretion in previous works or novel non-coding RNAs. 27.9% of transcripts were mapped into 242 predicted KEGG pathways and 6.16% of transcripts related to human disease and cancer. Of 39 448 transcripts with the coding sequence, at least 1501 transcripts (570 genes) related to the immune system process. The molecules of immune signalling pathway were almost presented, several transcripts with high expression in skin and stomach. Experiments showed that lipopolysaccharide or bacteria challenge stimulated pro-inflammatory cytokine production and activation of pro-inflammatory caspase-1. These frog's data can remarkably expand the existing genome or transcriptome resources of amphibians, especially immunity data. The entity of the data provides a valuable platform for further investigation on more detailed immune response in B. maxima and a comparative study with other amphibians.
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