ArticleBiomechanics and modeling in mechanobiology2014
Vascular deposition patterns for nanoparticles in an inflamed patient-specific arterial tree.
Article in Biomechanics and modeling in mechanobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Modeling of spatiotemporal dynamics of ligand-coated particle flow in targeted drug delivery processes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Multiscale physics-basedFrontiers in drug delivery · 2024Review
- Image-guided subject-specific modeling of glymphatic transport and amyloid deposition.Computer methods in applied mechanics and engineering · 2023Article
- A Novel Method for Improving the Accuracy of MR-derived Patient-specific Vascular Models using X-ray Angiography.Engineering with computers · 2022Article
- Image-based patient-specific flow simulations are consistent with stroke in pediatric cerebrovascular disease.Biomechanics and modeling in mechanobiology · 2021Article
- A mathematical model of hiPSC cardiomyocytes electromechanics.Physiological reports · 2021Article
- Modulating Lipoprotein Transcellular Transport and Atherosclerotic Plaque Formation in ApoEACS applied materials & interfaces · 2020Article
- Flow arrest intra-arterial delivery of small TAT-decorated and neutral micelles to gliomas.Journal of neuro-oncology · 2017Article
- Predicting different adhesive regimens of circulating particles at blood capillary walls.Microfluidics and nanofluidics · 2017Article
- Computational pharmacokinetic rationale for intra-arterial delivery to the brain.Drug delivery and translational research · 2016Article
- A computational study of cancer hyperthermia based on vascular magnetic nanoconstructs.Royal Society open science · 2016Article
- Liposome size and charge optimization for intraarterial delivery to gliomas.Drug delivery and translational research · 2016Article
- Intraarterial drug delivery for glioblastoma mutiforme: Will the phoenix rise again?Journal of neuro-oncology · 2015Review
- Magnetic resonance imaging-based computational modelling of blood flow and nanomedicine deposition in patients with peripheral arterial disease.Journal of the Royal Society, Interface · 2015Article
- Drug carrier interaction with blood: a critical aspect for high-efficient vascular-targeted drug delivery systems.Therapeutic delivery · 2015Review
- Reassessing the Role of Intra-Arterial Drug Delivery for Glioblastoma Multiforme Treatment.Journal of drug delivery · 2015Review
- Cerebral hypoperfusion-assisted intra-arterial deposition of liposomes in normal and glioma-bearing rats.Neurosurgery · 2015Article
- Cationic surface charge enhances early regional deposition of liposomes after intracarotid injection.Journal of neuro-oncology · 2014Article
- USNCTAM perspectives on mechanics in medicine.Journal of the Royal Society, Interface · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Inflammation, a precursor to many diseases including cancer and atherosclerosis, induces differential surface expression of specific vascular molecules. Blood-borne nanoparticles (NPs), loaded with therapeutic and imaging agents, can recognize and use these molecules as vascular docking sites. Here, a computational model is developed within the isogeometric analysis framework to understand and predict the vascular deposition of NPs within an inflamed arterial tree. The NPs have a diameter ranging from 0.1 to 2.0 μm and are decorated with antibodies directed toward three endothelial adhesion molecules, namely intravascular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin, whose surface density depends on the local wall shear stress. Results indicate VCAM-1 targeted NPs adhere more, with ICAM-1 directed NPs adhering least efficiently, resulting in approximately an order-of-magnitude lower average particle surface density. ICAM-1 and E-selectin directed 0.5 μm NPs are distributed more uniformly (heterogeneity index ≈ 0.9 and 1.0, respectively) over the bifurcating vascular branches compared to their VCAM-1 counterparts (heterogeneity index ≈ 1.4). When the NPs are coated with antibodies for VCAM-1 and E-selectin in equal proportions, a more uniform vascular distribution is achieved compared with VCAM-1-only targeted particles, thus demonstrating the advantage of NP multivalency in vascular targeting. Furthermore, the larger NPs (2 μm) adhere more (≈ 200%) in the lower branches compared to the upper branch. This computational framework provides insights into how size, ligand type, density, and multivalency can be manipulated to enhance NP vascular adhesion in an individual patient.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.