ReviewDer Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen2013
[Pathophysiology of multiple trauma : intensive care medicine and timing of treatment].
Review in Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 50 citations in OpenAlex.
- Trauma Induces Interleukin-17A Expression on Th17 Cells and CD4+ Regulatory T Cells as Well as Platelet Dysfunction.Frontiers in immunology · 2019Trial
- Older age and post-traumatic organ failure a TraumaRegister DGUEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Alcohol drinking leads to sex-dependent differentiation of T cells.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Observational
- Association of Blood Metabolomics Biomarkers with Brain Metabolites and Patient-Reported Outcomes as a New Approach in Individualized Diagnosis of Schizophrenia.International journal of molecular sciences · 2024Article
- Occult hypoperfusion and changes of systemic lipid levels after severe trauma: an analysis in a standardized porcine polytrauma model.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- The sequence of the treatment of combined fractures of the pelvis, spine, and extremities in polytraumatized patients.EFORT open reviews · 2023Review
- Age-related exacerbation of lung damage after trauma is associated with increased expression of inflammasome components.Frontiers in immunology · 2023Article
- Acute alcohol consumption increases systemic endotoxin bioactivity for days in healthy volunteers-with reduced intestinal barrier loss in female.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Facing Trauma and Surgical Emergency in Space: Hemorrhagic Shock.Frontiers in bioengineering and biotechnology · 2022Review
- The Role of Lactate for Sepsis in Polytrauma Patients, a Time related Analysis using the IBM Watson Trauma Pathway ExplorerJournal of surgery and research · 2022Article
- The journey of SARS-CoV-2 in human hosts: a review of immune responses, immunosuppression, and their consequences.Virulence · 2021Review
- Enhanced pro-inflammatory response and higher mortality rates in geriatric trauma patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2021Article
- Influence of Antibiotic Management on Microbial Selection and Infectious Complications After Trauma.Frontiers in medicine · 2021Article
- Cytological Effects of Serum Isolated from Polytraumatized Patients on Human Bone Marrow-Derived Mesenchymal Stem Cells.Stem cells international · 2021Article
- Early local neutralization of CC16 in sepsis‑induced ALI following blunt chest trauma leads to delayed mortality without benefitting overall survival.International journal of molecular medicine · 2020Article
- Different experimental multiple trauma models induce comparable inflammation and organ injury.Scientific reports · 2020Article
- Damage-associated molecular patterns in trauma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Review
- A nationwide fluidics biobank of polytraumatized patients: implemented by the Network "Trauma Research" (NTF) as an expansion to the TraumaRegister DGUEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Review
- Regulatory T Cells Modulate CD4 Proliferation after Severe Trauma via IL-10.Journal of clinical medicine · 2020Article
- Monotrauma is associated with enhanced remote inflammatory response and organ damage, while polytrauma intensifies both in porcine trauma model.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After severe multiple injuries (first hit) a two-phase immunological response with early hyperinflammation followed by immunosuppression can be observed. This process involves a variety of humoral and cellular factors. Depending on the individual predisposition, overall injury severity and injury pattern, both reactions can lead to sepsis and multiorgan failure. Various clinical and intensive care parameters indicate stabilization of specific organ functions. The clinical course can be positively influenced by adequate intensive care therapy, avoiding iatrogenic second hits by non-emergency surgical interventions during a phase of immunological dysregulation. Important decision parameters besides time to initial trauma include adequate oxygenation, no coagulopathy, declining inflammatory mediators and normalized serum lactate.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.