ArticleAmerican journal of hypertension2013
Plasma bicarbonate and odds of incident hypertension.
Article in American journal of hypertension, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Metabolic Acidosis in Patients with Chronic Kidney Disease: Diagnosis, Pathogenesis, and Treatment-A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Dietary acid load in health and disease.Pflugers Archiv : European journal of physiology · 2024Review
- Targeting the ASMase/S1P pathway protects from sortilin-evoked vascular damage in hypertension.The Journal of clinical investigation · 2022Article
- Base excess is associated with the risk of all-cause mortality in critically ill patients with acute myocardial infarction.Frontiers in cardiovascular medicine · 2022Article
- A Pilot Study of the Safety and Efficacy of Alkali Therapy on Vascular Function in Kidney Transplant Recipients.Kidney international reports · 2021Article
- COStroke and vascular neurology · 2021Article
- Lower serum bicarbonate is associated with an increased risk of acute kidney injury.Journal of nephrology · 2021Article
- Exhausted Capacity of Bicarbonate Buffer in Renal Failure Diagnosed Using Point of Care Analyzer.Diagnostics (Basel, Switzerland) · 2021Article
- Chronic Metabolic Acidosis Elicits Hypertension via Upregulation of Intrarenal Angiotensin II and Induction of Oxidative Stress.Antioxidants (Basel, Switzerland) · 2020Article
- Assessment of Plasma Sodium to Potassium Ratio, Renal Function, Markers of Oxidative Stress, Inflammation, and Endothelial Dysfunction in Nigerian Hypertensive Patients.International journal of hypertension · 2020Article
- Review
- Article
- Prospective relation of adolescent citrate excretion and net acid excretion capacity with blood pressure in young adulthood.American journal of physiology. Renal physiology · 2018Article
- Article
- Metabolic acidosis of chronic kidney disease and subclinical cardiovascular disease markers: Friend or foe?Medicine · 2017Article
- Independent associations between arterial bicarbonate, apnea severity and hypertension in obstructive sleep apnea.Respiratory research · 2017Article
- Role of Acid-Base Homeostasis in Diabetic Kidney Disease.Current diabetes reports · 2017Review
- Serum Bicarbonate Is Associated with Heart Failure in the Multi-Ethnic Study of Atherosclerosis.American journal of nephrology · 2017Article
- Use of Biomarkers in the Evaluation and Treatment of Hypertensive Patients.Current hypertension reports · 2016Review
- Association between lower serum bicarbonate and renal hyperfiltration in the general population with preserved renal function: a cross-sectional study.BMC nephrology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSeveral biomarkers of metabolic acidosis, including lower plasma bicarbonate, have been associated with prevalent hypertension in cross-sectional studies. We sought to examine prospectively whether lower plasma bicarbonate is associated with incident hypertension.
methodsWe conducted a prospective case-control study nested within the Nurses' Health Study II. Plasma bicarbonate was measured in 695 nonobese women without hypertension at time of blood draw who subsequently developed hypertension during 6 years of follow-up. Control subjects were matched to case subjects according to age, race, time and day of blood draw, and day of menstrual cycle. We used unconditional logistic regression to generate odds ratios (ORs) for development of hypertension by quintile of baseline plasma bicarbonate.
resultsAfter adjusting for matching factors, body mass index, family history of hypertension, plasma creatinine, and dietary and lifestyle factors, higher plasma bicarbonate was associated with lower odds of developing hypertension across quintiles (P for linear trend = 0.04). Those in the highest compared with the lowest quintile of plasma bicarbonate had 31% lower odds of developing hypertension (OR = 0.69; 95% confidence interval = 0.48-0.99). Further adjustment for diet-estimated net endogenous acid production, plasma insulin, 25-hydroxyvitamin D, and uric acid did not alter these findings.
conclusionsOur case-control study is consistent with a modest association between higher plasma bicarbonate and reduced odds of developing hypertension among nonobese women, although our findings are of borderline statistical significance. Further research is required to confirm this finding as part of a larger prospective cohort study and to elucidate the mechanism for this relation.
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Registered trials
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