Trial reportPediatric research2013
Septicemia mortality reduction in neonates in a heart rate characteristics monitoring trial.
Trial report in Pediatric research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03004482 (Noninvasive Monitoring and Diagnosis of Physiologic Disturbances in Term and Preterm Newborns Using Video Analysis Techniques), which is not on this map. Cited by 82 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Noninvasive Monitoring and Diagnosis of Physiologic Disturbances in Term and Preterm Newborns Using Video Analysis Techniques
Who cites it
82 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Heart Rate Characteristics Monitoring for Late-Onset Sepsis in Preterm Infants: A Systematic Review.Neonatology · 2023Pooled it
- Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials.Pediatric research · 2022Pooled it
- Contemporary Trends in Global Mortality of Sepsis Among Young Infants Less Than 90 Days: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- A randomized controlled trial of artificial intelligence-based analytics for clinical deterioration.Scientific reports · 2026Trial
- Impact of race on heart rate characteristics monitoring in very low birth weight infants.Pediatric research · 2023Trial
- Cardiorespiratory measures shortly after extubation and extubation outcomes in extremely preterm infants.Pediatric research · 2023Trial
- The effect of sleeping position on heart rate variability in newborns.BMC pediatrics · 2020Trial
- Mortality and Neurodevelopmental Outcomes in the Heart Rate Characteristics Monitoring Randomized Controlled Trial.The Journal of pediatrics · 2020Trial
- Complex signals bioinformatics: evaluation of heart rate characteristics monitoring as a novel risk marker for neonatal sepsis.Journal of clinical monitoring and computing · 2014Trial
- Infection and other clinical correlates of abnormal heart rate characteristics in preterm infants.The Journal of pediatrics · 2014Trial
- Early risk stratification of late-onset sepsis in very preterm infants by intestinal microbiota profiling: a multicenter case-control validation study.Gut microbes · 2026Article
- Temporal trends in heart rate characteristic index preceding necrotizing enterocolitis in preterm infants.Journal of neonatal-perinatal medicine · 2026Article
- Cardiorespiratory signatures of necrotizing enterocolitis: a 4-NICU study of very low birth weight infants.Pediatric research · 2026Article
- A machine learning system enables just-in-time risk-stratified sepsis evaluations in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Neonatal sepsis and cardiovascular dysfunction II: assessment.Pediatric research · 2026Review
- Vital signs, demographics, and clinical events for low-birth-weight infants from four intensive care units.medRxiv : the preprint server for health sciences · 2026Article
- Future perspectives of heart rate and oxygenation monitoring in the neonatal intensive care unit - a narrative review.Journal of clinical monitoring and computing · 2025Review
- AI models in clinical neonatology: a review of modeling approaches and a consensus proposal for standardized reporting of model performance.Pediatric research · 2025Review
- Clinical correlates of a high cardiorespiratory risk score for very low birth weight infants.Pediatric research · 2025Article
- Aligning prediction models with clinical information needs: infant sepsis case study.JAMIA open · 2025Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
backgroundAbnormal heart rate characteristics (HRC) wax and wane in early stages of culture-positive, late-onset septicemia (LOS) in patients in the neonatal intensive care unit (NICU). Continuously monitoring an HRC index leads to a reduction in mortality among very low birth weight (VLBW) infants. We hypothesized that the reduction in mortality was due to a decrease in septicemia-associated mortality.
methodsThis is a secondary analysis of clinical and HRC data from 2,989 VLBW infants enrolled in a randomized clinical trial of HRC monitoring in nine NICUs from 2004 to 2010.
resultsLOS was diagnosed 974 times in 700 patients, and the incidence and distribution of organisms were similar in HRC display and nondisplay groups. Mortality within 30 d of LOS was lower in the HRC display as compared with the nondisplay group (11.8 vs. 19.6%; relative risk: 0.61; 95% confidence interval: 0.43, 0.87; P < 0.01), but mortality reduction was not statistically significant for patients without LOS. There were fewer large, abrupt increases in the HRC index in the days leading up to LOS diagnosis in infants whose HRC index was displayed.
conclusionContinuous HRC monitoring is associated with a lower septicemia-associated mortality in VLBW infants, possibly due to diagnosis earlier in the course of illness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.