ArticleDevelopment (Cambridge, England)2013
CAF-1 promotes Notch signaling through epigenetic control of target gene expression during Drosophila development.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- The Drosophila histone variant H2Av facilitates Notch signaling activity in a two-tier regulatory fashion.Cell communication and signaling : CCS · 2025Article
- Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development.Blood advances · 2023Article
- The mitochondrial ribosomal protein mRpL4 regulates Notch signaling.EMBO reports · 2023Article
- GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila.Cell death & disease · 2022Article
- Identification of a new allele of O-fucosyltransferase 1 involved in Drosophila intestinal stem cell regulation.Biology open · 2021Article
- The CAF-1 complex couples Hippo pathway target gene expression and DNA replication.Molecular biology of the cell · 2019Article
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- Inhibition of Notch signaling by the p105 and p180 subunits ofJournal of cell science · 2019Article
- Emerging roles of the histone chaperone CAF-1 in cellular plasticity.Current opinion in genetics & development · 2017Review
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- A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks.Nucleic acids research · 2016Article
- The Candida albicans Histone Acetyltransferase Hat1 Regulates Stress Resistance and Virulence via Distinct Chromatin Assembly Pathways.PLoS pathogens · 2015Article
- Chromatin signatures at Notch-regulated enhancers reveal large-scale changes in H3K56ac upon activation.The EMBO journal · 2015Article
- Histone storage and deposition in the early Drosophila embryo.Chromosoma · 2015Review
- Drosophila domino Exhibits Genetic Interactions with a Wide Spectrum of Chromatin Protein-Encoding Loci.PloS one · 2015Article
- Histone chaperone CAF-1: essential roles in multi-cellular organism development.Cellular and molecular life sciences : CMLS · 2015Review
- E(y)1/TAF9 mediates the transcriptional output of Notch signaling in Drosophila.Journal of cell science · 2014Article
- Various applications of TALEN- and CRISPR/Cas9-mediated homologous recombination to modify the Drosophila genome.Biology open · 2014Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The histone chaperone CAF-1 is known for its role in DNA replication-coupled histone deposition. However, loss of function causes lethality only in higher multicellular organisms such as mice and flies, but not in unicellular organisms such as yeasts, suggesting that CAF-1 has other important functions than histone deposition during animal development. Emerging evidence indicates that CAF-1 also has a role in higher order chromatin organization and heterochromatin-mediated gene expression; it remains unclear whether CAF-1 has a role in specific signaling cascades to promote gene expression during development. Here, we report that knockdown of one of the subunits of Drosophila CAF-1, dCAF-1-p105 (Caf1-105), results in phenotypes that resemble those of, and are augmented synergistically by, mutations of Notch positive regulatory pathway components. Depletion of dCAF-1-p105 leads to abrogation of cut expression and to downregulation of other Notch target genes in wing imaginal discs. dCAF-1-p105 is associated with Suppressor of Hairless [Su(H)] and regulates its binding to the enhancer region of E(spl)mβ. The association of dCAF-1-p105 with Su(H) on chromatin establishes an active local chromatin status for transcription by maintaining a high level of histone H4 acetylation. In response to induced Notch activation, dCAF-1 associates with the Notch intracellular domain to activate the expression of Notch target genes in cultured S2 cells, manifesting the role of dCAF-1 in Notch signaling. Together, our results reveal a novel epigenetic function of dCAF-1 in promoting Notch pathway activity that regulates normal Drosophila development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.