ReviewNature reviews. Neuroscience2013
The brain reward circuitry in mood disorders.
Review in Nature reviews. Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 992 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
992 citing papers in PubMed.
- Similarities and differences in carotid artery, hemodynamic, and autonomic reactivity induced by mental stress or cold in adults: A randomized crossover study.Physiological reports · 2026Trial
- The Effect of Digital Addiction Training on University Students' Digital Addiction, Sleep Quality, and Orexin-A Levels: Randomized Controlled Trial.BMC psychology · 2025Trial
- Selective KOR antagonist alters functional patch sizes in individualized brain system: results from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS).Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- Sustained effects of repeated levodopa (L-DOPA) administration on reward circuitry, effort-based motivation, and anhedonia in depressed patients with higher inflammation.Brain, behavior, and immunity · 2025Trial
- Effect of DLPFC rTMS on anhedonia and alpha asymmetry in depressed patients.Scientific reports · 2025Trial
- Nucleus Accumbens and Ventral Tegmental Area Functional Connectivity as a Marker of Reward Sensitivity in Infancy.Developmental science · 2026Article
- Extinction-recruited prefrontal-hypothalamic pathway encodes positive affect to sustain fear extinction in posttraumatic stress mouse model.The Journal of clinical investigation · 2026Article
- Reviewing Physiological Measures of Implicit Consumer Response to Food.Foods (Basel, Switzerland) · 2026Review
- Neuropathophysiological changes associated with mirtazapine treatment response in major depressive disorder: insights into bottom-up dopaminergic pathways and prefrontal control networks.European archives of psychiatry and clinical neuroscience · 2026Article
- The Role of Kappa-Opioid Receptor/Dynorphin System in Modulating Neural-Circuits of Depression and Anxiety-A Review.Journal of cellular and molecular medicine · 2026Review
- Selective impairment of long-term depression in accumbal D1R+ MSNs involves calcium-permeable AMPARs in early Alzheimer's disease.Neurobiology of disease · 2026Article
- Hippocampal-cingulate dynamics in the human brain link reinforcement-learning and memory.bioRxiv : the preprint server for biology · 2026Article
- Cell-type-specific disruption of nucleus accumbens social representations in a mouse model of autism.Neuron · 2026Article
- The multilevel exploration test, a novel paradigm to measure exploratory behavior in depression animal models and the involvement of the PL-ZI circuit.Acta pharmacologica Sinica · 2026Article
- Cannabidiol Ameliorates Blood-Brain Barrier Dysfunction and Inhibits Memory Astrocytes Activation in Mice With Sickness-Like Behaviors.CNS neuroscience & therapeutics · 2026Article
- Temporal Dynamics of Reward Dysfunction in Psychiatric Disorders: Memory-Derived Value, Incentive Salience, Hedonic Impact, and Value Updating.Biological psychiatry global open science · 2026Review
- Multilevel sex-influenced neurobiological signatures of early life adversity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Synaptic Actions of Estradiol in the Brain's Reward System: Linking Mechanisms to Behavior and Disease.Biological psychiatry global open science · 2026Review
- Bioactive dietary polyphenols modulate hippocampal inflammasome activation and sex-specific affective behavioral deficits following peripheral Foxp3Research square · 2026Article
- Towards precision psychiatry: initial foundations and future directions.Nature reviews. Drug discovery · 2026Review
932 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
Mood disorders are common and debilitating conditions characterized in part by profound deficits in reward-related behavioural domains. A recent literature has identified important structural and functional alterations within the brain's reward circuitry--particularly in the ventral tegmental area-nucleus accumbens pathway--that are associated with symptoms such as anhedonia and aberrant reward-associated perception and memory. This Review synthesizes recent data from human and rodent studies from which emerges a circuit-level framework for understanding reward deficits in depression. We also discuss some of the molecular and cellular underpinnings of this framework, ranging from adaptations in glutamatergic synapses and neurotrophic factors to transcriptional and epigenetic mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.