ArticleScientific reports2013
Effects of bursty protein production on the noisy oscillatory properties of downstream pathways.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Revisiting the Reduction of Stochastic Models of Genetic Feedback Loops with Fast Promoter Switching.Biophysical journal · 2019Article
- Analytical approximations for spatial stochastic gene expression in single cells and tissues.Journal of the Royal Society, Interface · 2016Article
- Variance-corrected Michaelis-Menten equation predicts transient rates of single-enzyme reactions and response times in bacterial gene-regulation.Scientific reports · 2015Article
- Regulation of burstiness by network-driven activation.Scientific reports · 2015Article
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2 authors.
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Abstract
Experiments show that proteins are translated in sharp bursts; similar bursty phenomena have been observed for protein import into compartments. Here we investigate the effect of burstiness in protein expression and import on the stochastic properties of downstream pathways. We consider two identical pathways with equal mean input rates, except in one pathway proteins are input one at a time and in the other proteins are input in bursts. Deterministically the dynamics of these two pathways are indistinguishable. However the stochastic behavior falls in three categories: (i) both pathways display or do not display noise-induced oscillations; (ii) the non-bursty input pathway displays noise-induced oscillations whereas the bursty one does not; (iii) the reverse of (ii). We derive necessary conditions for these three cases to classify systems involving autocatalysis, trimerization and genetic feedback loops. Our results suggest that single cell rhythms can be controlled by regulation of burstiness in protein production.
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