ArticleRespiratory physiology & neurobiology2013
Heterogeneity and matching of ventilation and perfusion within anatomical lung units in rats.
Article in Respiratory physiology & neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Lung endothelium, tau, and amyloids in health and disease.Physiological reviews · 2024Review
- Ventilation/Perfusion Relationships and Gas Exchange: Measurement Approaches.Comprehensive Physiology · 2020Review
- lapdMouse: associating lung anatomy with local particle deposition in mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Ventilation/Perfusion Matching: Of Myths, Mice, and Men.Physiology (Bethesda, Md.) · 2019Review
- Gravity outweighs the contribution of structure to passive ventilation-perfusion matching in the supine adult human lung.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Comparison of CT-derived ventilation maps with deposition patterns of inhaled microspheres in rats.Experimental lung research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Prior studies exploring the spatial distributions of ventilation and perfusion have partitioned the lung into discrete regions not constrained by anatomical boundaries and may blur regional differences in perfusion and ventilation. To characterize the anatomical heterogeneity of regional ventilation and perfusion, we administered fluorescent microspheres to mark regional ventilation and perfusion in five Sprague-Dawley rats and then using highly automated computer algorithms, partitioned the lungs into regions defined by anatomical structures identified in the images. The anatomical regions ranged in size from the near-acinar to the lobar level. Ventilation and perfusion were well correlated at the smallest anatomical level. Perfusion and ventilation heterogeneity were relatively less in rats compared to data previously published in larger animals. The more uniform distributions may be due to a smaller gravitational gradient and/or the fewer number of generations in the distribution trees before reaching the level of gas exchange, making regional matching of ventilation and perfusion less extensive in small animals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.