ArticleScientific reports2013
Upregulation of aquaporin expression in the salivary glands of heat-acclimated rats.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Repeated heat exposure upregulates skeletal muscle aquaporin-4 expression in male mice.Physiological reports · 2026Article
- The Impact of High-Temperature Stress on Gut Microbiota and Reproduction in Siberian Hamsters (Microorganisms · 2024Article
- Aquaporin-5 Dynamic Regulation.International journal of molecular sciences · 2023Review
- Effects of 4-hexylresorcinol administration on the submandibular glands in a growing rat model.Head & face medicine · 2022Article
- Article
- Ginger facilitates cell migration and heat tolerance in mouse fibroblast cells.Molecular medicine reports · 2021Article
- Salivary Immunoglobulin A Secretion and Polymeric Ig Receptor Expression in the Submandibular Glands Are Enhanced in Heat-Acclimated Rats.International journal of molecular sciences · 2020Article
- Evaluation of Aquaporins 1 and 5 Expression in Rat Parotid Glands After Volumetric Modulated Arc Radiotherapy and Use of Low-Level Laser Therapy at Different Times.Journal of lasers in medical sciences · 2020Article
- Localization of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) α, β, γ in the three major salivary glands in situ of mice and their response to β-adrenoceptor stimulation.Journal of anatomy · 2019Article
- Genetic diversity and selection signatures of the beef 'Charolais de Cuba' breed.Scientific reports · 2018Article
- Cytosolic phosphoenolpyruvate carboxykinase is a response gene involved in porcine adipocyte adaptation to heat stress.Journal of animal science · 2018Article
- The Process of Acclimation to Chronic Hypoxia Leads to Submandibular Gland and Periodontal Alterations: An Insight on the Role of Inflammatory Mediators.Mediators of inflammation · 2018Article
- Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands.FEBS open bio · 2018Article
- The expression of water channel proteins during human salivary gland development: a topographic study of aquaporins 1, 3 and 5.Journal of molecular histology · 2017Article
- SMN regulation in SMA and in response to stress: new paradigms and therapeutic possibilities.Human genetics · 2017Review
- Long-term HIF-1α transcriptional activation is essential for heat-acclimation-mediated cross tolerance: mitochondrial target genes.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Article
- Emerging roles of aquaporins in relation to the physiology of blood-feeding arthropods.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Review
- Heat acclimation and cross tolerance to hypoxia: Bridging the gap between cellular and systemic responses.Temperature (Austin, Tex.)Review
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is known that aquaporin (AQP) 5 expression in the apical membrane of acinar cells in salivary glands is important for the secretion of saliva in rodents and humans. Although heat acclimation enhances saliva secretion in rodents, the molecular mechanism of how heat induces saliva secretion has not been determined. Here, we found that heat acclimation enhanced the expression of AQP5 and AQP1 in rat submandibular glands concomitant with the promotion of the HIF-1α pathway, leading to VEGF induction and CD31-positive angiogenesis. The apical membrane distribution of AQP5 in serous acinar cells enhanced after heat acclimation, while AQP1 expression was restricted to the endothelial cells in the submandibular glands. A network of AQPs may be involved in heat-acclimated regulation in saliva secretion. Because AQPs probably plays a crucial role in saliva secretion in humans, these findings may lead to a novel strategy for treating saliva hyposecretion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.