Evidence map›Paper›PMID 23942142›Full record

ReviewSeminars in cell & developmental biology2014

Intercellular adhesion molecule 1: recent findings and new concepts involved in mammalian spermatogenesis.

Dolores D Mruk, Xiang Xiao, Marta Lydka, Michelle W M Li, Barbara Bilinska, C Yan Cheng

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Molecular Docking for Active Compounds ofActa informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2018
    Article
  7. Article
  8. Polydeoxyribonucleotide, an Adenosine-A2Frontiers in pharmacology · 2016
    Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Dolores D MrukCenter for Biomedical Research, Population Council, 1230 York Avenue, New York, NY 10065, United States. Electronic address: mruk@popcbr.rockefeller.edu.
Xiang XiaoCenter for Biomedical Research, Population Council, 1230 York Avenue, New York, NY 10065, United States.
Marta LydkaCenter for Biomedical Research, Population Council, 1230 York Avenue, New York, NY 10065, United States.
Michelle W M LiCenter for Biomedical Research, Population Council, 1230 York Avenue, New York, NY 10065, United States.
Barbara BilinskaInstitute of Zoology, Department of Endocrinology, The Jagiellonian University, Gronostajowa 9, 30-387 Krakow, Poland.
C Yan ChengCenter for Biomedical Research, Population Council, 1230 York Avenue, New York, NY 10065, United States.
Population Council · USJagiellonian University · PL

Funding

SPECIALIZED CONTRACEPTIVE DEVELOPMENT RESEARCH CENTERU54HD029990 · NICHD · POPULATION COUNCIL · PI CHENG, C. YAN · 1992 to 2016
$27.7M
The biology of blood-testis barrier dynamicsR01HD056034 · NICHD · POPULATION COUNCIL · PI CHENG, C. YAN · 2009 to 2018
$3.4M
Biology of desmosome-gap junctions in the testisR03HD061401 · NICHD · POPULATION COUNCIL · PI MRUK, DOLORES D · 2009 to 2010
$160k
NICHD NIH HHS R01 HD056034NICHD NIH HHS R03 HD061401NICHD NIH HHS U54 HD029990
6 · The paper itself

Abstract

Spermatogenesis, the process of spermatozoa production, is regulated by several endocrine factors, including testosterone, follicle stimulating hormone, luteinizing hormone and estradiol 17β. For spermatogenesis to reach completion, developing germ cells must traverse the seminiferous epithelium while remaining transiently attached to Sertoli cells. If germ cell adhesion were to be compromised for a period of time longer than usual, germ cells would slough from the seminiferous epithelium and infertility would result. Presently, Sertoli-germ cell adhesion is known to be mediated largely by classical and desmosomal cadherins. More recent studies, however, have begun to expand long-standing concepts and to examine the roles of other proteins such as intercellular adhesion molecules. In this review, we focus on the biology of intercellular adhesion molecules in the mammalian testis, hoping that this information is useful in the design of future studies.

Indexed as

AnimalsBlood-Testis BarrierCell AdhesionIntercellular Adhesion Molecule-1MaleMAP Kinase Signaling SystemMiceSeminiferous EpitheliumSertoli CellsSpermatogenesisSpermatozoaIntercellular Adhesion Molecule-1Cell junctionGerm cellICAMSertoli cellTestis

Identifiers

PMID23942142
PMCPMC3921265
OpenAlexW2024277888

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.