ArticleBritish journal of cancer2013
Prospective validation of the breast cancer risk prediction model BOADICEA and a batch-mode version BOADICEACentre.
Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Development and performance of female breast cancer incidence risk prediction models: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Validation of the BOADICEA model for predicting the likelihood of carrying pathogenic variants in eight breast and ovarian cancer susceptibility genes.Scientific reports · 2023Article
- Validation Study on Risk-Reduction Activities after Exposure to a Personalized Breast Cancer Risk-Assessment Education Tool in High-Risk Women in the WISDOM Study.Research square · 2023Article
- Prospective validation of the BOADICEA multifactorial breast cancer risk prediction model in a large prospective cohort study.Journal of medical genetics · 2022Article
- Body mass index rebound and pubertal timing in girls with and without a family history of breast cancer: the LEGACY girls study.International journal of epidemiology · 2022Article
- Personalized Risk Assessment for Prevention and Early Detection of Breast Cancer: Integration and Implementation (PERSPECTIVE I&I).Journal of personalized medicine · 2021Article
- Ability of known colorectal cancer susceptibility SNPs to predict colorectal cancer risk: A cohort study within the UK Biobank.PloS one · 2021Article
- Article
- Regular use of aspirin and other non-steroidal anti-inflammatory drugs and breast cancer risk for women at familial or genetic risk: a cohort study.Breast cancer research : BCR · 2019Article
- Association of Prepubertal and Adolescent Androgen Concentrations With Timing of Breast Development and Family History of Breast Cancer.JAMA network open · 2019Article
- Clinicians' use of breast cancer risk assessment tools according to their perceived importance of breast cancer risk factors: an international survey.Journal of community genetics · 2019Article
- Risks of breast or ovarian cancer in BRCA1 or BRCA2 predictive test negatives: findings from the EMBRACE study.Genetics in medicine : official journal of the American College of Medical Genetics · 2018Article
- Use of the BOADICEA Web Application in clinical practice: appraisals by clinicians from various countries.Familial cancer · 2018Article
- Pubertal development in girls by breast cancer family history: the LEGACY girls cohort.Breast cancer research : BCR · 2017Article
- Testing for Gene-Environment Interactions Using a Prospective Family Cohort Design: Body Mass Index in Early and Later Adulthood and Risk of Breast Cancer.American journal of epidemiology · 2017Article
- Breast cancer risk prediction using a polygenic risk score in the familial setting: a prospective study from the Breast Cancer Family Registry and kConFab.Genetics in medicine : official journal of the American College of Medical Genetics · 2017Article
- Recommendations on breast cancer screening and prevention in the context of implementing risk stratification: impending changes to current policies.Current oncology (Toronto, Ont.) · 2016Article
- Cohort Profile: The Breast Cancer Prospective Family Study Cohort (ProF-SC).International journal of epidemiology · 2016Article
- iPrevent®: a tailored, web-based, decision support tool for breast cancer risk assessment and management.Breast cancer research and treatment · 2016Article
- Breast Cancer Risk Prediction Using Clinical Models and 77 Independent Risk-Associated SNPs for Women Aged Under 50 Years: Australian Breast Cancer Family Registry.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundBreast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) is a risk prediction algorithm that can be used to compute estimates of age-specific risk of breast cancer. It is uncertain whether BOADICEA performs adequately for populations outside the United Kingdom.
methodsUsing a batch mode version of BOADICEA that we developed (BOADICEACentre), we calculated the cumulative 10-year invasive breast cancer risk for 4176 Australian women of European ancestry unaffected at baseline from 1601 case and control families in the Australian Breast Cancer Family Registry. Based on 115 incident breast cancers, we investigated calibration, discrimination (using receiver-operating characteristic (ROC) curves) and accuracy at the individual level.
resultsThe ratio of expected to observed number of breast cancers was 0.92 (95% confidence interval (CI) 0.76-1.10). The E/O ratios by subgroups of the participant's relationship to the index case and by the reported number of affected relatives ranged between 0.83 and 0.98 and all 95% CIs included 1.00. The area under the ROC curve was 0.70 (95% CI 0.66-0.75) and there was no evidence of systematic under- or over-dispersion (P=0.2).
conclusionBOADICEA is well calibrated for Australian women, and had good discrimination and accuracy at the individual level.
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