ArticleAmerican journal of physiology. Endocrinology and metabolism2013
Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes.
Article in American journal of physiology. Endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Proteomic changes induced by longevity-promoting interventions in mice.GeroScience · 2024Article
- Growth hormone receptor gene disruption.Vitamins and hormones · 2023Article
- Lysosomal targetomics ofAutophagy · 2022Article
- Mice with gene alterations in the GH and IGF family.Pituitary · 2022Review
- Elevated metallothionein expression in long-lived species mediates the influence of cadmium accumulation on aging.GeroScience · 2021Article
- Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice.Aging · 2020Article
- Identification and Application of Gene Expression Signatures Associated with Lifespan Extension.Cell metabolism · 2019Article
- The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects.Frontiers in endocrinology · 2018Review
- mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice.Aging cell · 2017Article
- Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity.Cell metabolism · 2015Article
- Article
- Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice.Endocrinology · 2015Article
- Article
- Expression of apoptosis-related genes in liver-specific growth hormone receptor gene-disrupted mice is sex dependent.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice.Archives of endocrinology and metabolismReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Detoxification of ingested xenobiotic chemicals, and of potentially toxic endogenous metabolites, is carried out largely through a series of enzymes synthesized in the liver, sometimes called "xenobiotic metabolizing enzymes" (XME). Expression of these XME is sexually dimorphic in rodents and humans, with many of the XME expressed at higher levels in females. This expression pattern is thought to be regulated, in part, by the sex differences in circadian growth hormone (GH) pulsatility. We have evaluated mRNA, in the liver, for 52 XME genes in male and female mice of four mutant stocks, with diminished levels of GH receptor (GHR) either globally (GKO), or in liver (LKO), fat (FKO), or muscle (MKO) tissue specifically. The data show complex, sex-specific changes. For some XME, the expression pattern is consistent with direct control of hepatic mRNA by GHR in the liver. In contrast, other XME show evidence for indirect pathways in which hepatic XME expression is altered by GH signals in fat or skeletal muscle. The effects of GHR-null mutations on glucose control, responses to dietary interventions, steroid metabolism, detoxification pathways, and lifespan may depend on a mixture of direct hepatic effects and cross talk between different GH-responsive tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.