ArticleThe journal of spinal cord medicine2013
A prospective report on the prevalence of heart rate and blood pressure abnormalities in veterans with spinal cord injuries.
Article in The journal of spinal cord medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03602014 (Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Identification and Management of Cardiometabolic Risk after Spinal Cord Injury.The journal of spinal cord medicine · 2019Guideline
- Effect of Body Weight-Supported Treadmill Training on Cardiovascular and Pulmonary Function in People With Spinal Cord Injury: A Systematic Review.Topics in spinal cord injury rehabilitation · 2019Pooled it
- Identification and Management of Cardiometabolic Risk after Spinal Cord Injury: Clinical Practice Guideline for Health Care Providers.Topics in spinal cord injury rehabilitation · 2018Guideline
- Clinical trial of home blood pressure monitoring following midodrine administration in hypotensive individuals with spinal cord injury.The journal of spinal cord medicine · 2023Trial
- Double-blinded, placebo-controlled crossover trial to determine the effects of midodrine on blood pressure during cognitive testing in persons with SCI.Spinal cord · 2020Trial
- Effects of midodrine and L-NAME on systemic and cerebral hemodynamics during cognitive activation in spinal cord injury and intact controls.Physiological reports · 2016Trial
- Primary Care in the Spinal Cord Injury Population: Things to Consider in the Ongoing Discussion.Current physical medicine and rehabilitation reports · 2023Review
- "It Helps Me With Everything": A Qualitative Study of the Importance of Exercise for Individuals With Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2022Article
- Spinal Cord Injury Increases Pro-inflammatory Cytokine Expression in Kidney at Acute and Sub-chronic Stages.Inflammation · 2021Article
- Heart rate and blood pressure response improve the prediction of orthostatic cardiovascular dysregulation in persons with chronic spinal cord injury.Physiological reports · 2020Article
- Prolonged Targeted Cardiovascular Epidural Stimulation Improves Immunological Molecular Profile: A Case Report in Chronic Severe Spinal Cord Injury.Frontiers in systems neuroscience · 2020Article
- A comparison of passive hindlimb cycling and active upper-limb exercise provides new insights into systolic dysfunction after spinal cord injury.American journal of physiology. Heart and circulatory physiology · 2017Article
- Inter-day reliability of blood pressure and cerebral blood flow velocities in persons with spinal cord injury and intact controls.The journal of spinal cord medicine · 2017Article
- Dynamic wheelchair seating positions impact cardiovascular function after spinal cord injury.PloS one · 2017Article
- Diurnal blood pressure and urine production in acute spinal cord injury compared with controls.Spinal cord · 2017Observational
- Prevalence of abnormal systemic hemodynamics in veterans with and without spinal cord injury.Archives of physical medicine and rehabilitation · 2015Observational
- Impact of blood pressure dysregulation on health-related quality of life in persons with spinal cord injury: development of a conceptual model.Archives of physical medicine and rehabilitation · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDecentralized autonomic cardiovascular regulation may lead to increased prevalence of heart rate (HR) and blood pressure (BP) abnormalities in veterans with SCI. In addition, comorbid medical conditions and prescription medication use may increase HR and BP abnormalities. These abnormalities include bradycardia, and tachycardia, hypotension, hypertension as well as autonomic dysreflexia and orthostatic hypotension; the prevalence of which is unknown.
designHR and BP data were measured during a routine annual physical examination in 64 veterans with SCI. Measurements of HR and BP were recorded in the seated and supine positions to document the influence of body position and to document intra-subject variability in these assessments.
resultsAll subjects were chronically injured (20 ± 14 years), 33 subjects were tetraplegic (T: C3-C8), nine had high paraplegia (HP: T1-T6), and 22 had low paraplegia (LP: T7-L2). Regardless of position, the prevalence of bradycardia was increased in the T group, whereas prevalence of tachycardia was increased in the HP and LP groups. Systolic hypotension was more common in the T and HP groups than the LP group and positional effects were most evident in the T group. Systolic hypertension was comparable in the T and HP groups but was twice as prevalent in the LP group. Increased prevalence of individuals with three or more medical conditions and prescribed three or more medications which might influence HR and BP was observed.
conclusionDecentralized autonomic regulation, comorbid medical conditions, and prescription medication use in veterans with SCI result in HR and BP abnormalities; our data suggest that these abnormalities vary depending on the level of injury and orthostatic positioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.