SynthesisJournal of experimental & clinical cancer research : CR2013
Striking life events associated with primary breast cancer susceptibility in women: a meta-analysis study.
Synthesis in Journal of experimental & clinical cancer research : CR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05984914 (Psychological and Biological Outcomes in Breast Cancer Patients After Pythagorean Self-Awareness Intervention.), which is not on this map. Cited by 31 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Psychological and Biological Outcomes in Breast Cancer Patients After Pythagorean Self-Awareness Intervention.
Who cites it
31 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Mapping Psychosocial Determinants for Cancer Onset: An Umbrella Review.Psycho-oncology · 2026Pooled it
- Psychosocial factors and the risk of cancer: An individual-participant data meta-analysis.Cancer · 2026Pooled it
- Chronic psychosocial stress: a role in breast cancer etiology?Frontiers in oncology · 2026Pooled it
- Risk factors for breast cancer: an umbrella review of observational cohort studies and causal relationship analysis.Frontiers in oncology · 2025Pooled it
- Psychosocial interventions reduce cortisol in breast cancer patients: systematic review and meta-analysis.Frontiers in psychology · 2023Pooled it
- Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder.PloS one · 2018Pooled it
- Forming a Stress Management and Health Promotion Program for Women Undergoing Chemotherapy for Breast Cancer: A Pilot Randomized Controlled Trial.Integrative cancer therapies · 2016Trial
- Stress and risk of breast cancer; findings from a large population-based incident case-control study.Scientific reports · 2026Article
- Long-term impact of stressful life events on breast cancer risk: A 36-year genetically informed prospective study in the Finnish Twin Cohort.International journal of cancer · 2026Article
- Chronic stress: a fourth etiology in tumorigenesis?Molecular cancer · 2025Review
- Review
- Major Stressful Life Events and the Risk of Pancreatic, Head and Neck Cancers: A Case-Control Study.Cancers · 2024Article
- Association between stress, depression or anxiety and cancer: Rapid review of reviews.Comprehensive psychoneuroendocrinology · 2023Review
- Epigenetic Determinants of Racial Disparity in Breast Cancer: Looking beyond Genetic Alterations.Cancers · 2022Review
- The Role of Psychologic Stress in Cancer Initiation: Clinical Relevance and Potential Molecular Mechanisms.Cancer research · 2021Review
- The Role of Stress in Breast Cancer Incidence: Risk Factors, Interventions, and Directions for the Future.International journal of environmental research and public health · 2021Review
- Studying Depression, Anxiety, Distress and Somatisation in a Community Sample of 2,425 Adults in Greece.EMBnet.journal · 2021Article
- Influence of Psychological Factors in Breast and Lung Cancer Risk - A Systematic Review.Frontiers in psychology · 2021Review
- Life events as predictors for disability pension due to musculoskeletal diagnoses: a cohort study of Finnish twins.International archives of occupational and environmental health · 2020Article
- Major Stressful Life Events and Risk of Developing Lung Cancer: A Case-Control Study.Clinical Medicine Insights. Oncology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe association between striking life events, an important stress and acute anxiety disorder, and the occurrence of primary breast cancer is unclear. The current meta-analysis was designed to assess the relationship between striking life events and primary breast cancer incidence in women.
methodsSystematic computerized searching of the PubMed, ScienceDirect, Embase, and BMJ databases with the combinations of controlled descriptors from Mesh, including breast cancer, breast tumor, cancer of breast, mammary carcinoma, life events, life change events, case-control studies, case-base studies, cohort study, and cohort analysis and identified a total of 307 papers published from January 1995 to April 2012. Following evaluation of methodological quality with the Downs & Black criteria, seven case-control or cohort studies were selected and the association between striking life events and primary breast cancer incidence in women was measured using random effect or fixed-effect odds ratios combined with 95% confidence interval.
resultsThe seven studies included in the final meta-analysis included 99,807 women. A meta-analysis showed that the pooled OR for striking life events and breast cancer was 1.51 (95% CI 1.15 - 1.97, P = 0.003), indicating that women with striking life events were at 1.5-fold greater risk of developing breast cancer. The pooled OR for severe striking life events and breast cancer was 2.07 (95% CI 1.06 - 4.03), indicating that women with severe striking life events were at 2-fold greater risk of developing breast cancer.
conclusionsThe current meta-analysis showed significant evidence for a positive association between striking life events and primary breast cancer incidence in women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.