Trial reportThyroid : official journal of the American Thyroid Association2014
Subclinical thyroid dysfunction and functional capacity among elderly.
Trial report in Thyroid : official journal of the American Thyroid Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- Does low serum TSH within the normal range have negative impact on physical exercise capacity and quality of life of healthy elderly people?Archives of endocrinology and metabolism · 2015Trial
- Effects of discontinuation of levothyroxine treatment in older adults: protocol for a self-controlled trial.BMJ open · 2023Article
- Free thyroxine but not TSH levels are associated with decline in functional status in a cohort of geriatric outpatients.European geriatric medicine · 2022Article
- Expert consensus on diagnosis and treatment for elderly with thyroid diseases in China (2021).Aging medicine (Milton (N.S.W)) · 2021Article
- Subclinical Hypothyroidism: Prevalence, Health Impact, and Treatment Landscape.Endocrinology and metabolism (Seoul, Korea) · 2021Article
- Diagnosis and treatment of hypothyroidism in the elderly.Endocrine · 2019Review
- Heart rate response to graded exercise test of elderly subjects in different ranges of TSH levels.Archives of endocrinology and metabolism · 2018Article
- Hypothyroidism in hospitalized elderly patients: a sign of worse prognosis.Journal of endocrinological investigation · 2017Article
- The debate on treating subclinical hypothyroidism.Singapore medical journal · 2016Review
- Levothyroxine treatment of mild subclinical hypothyroidism: a review of potential risks and benefits.Therapeutic advances in endocrinology and metabolism · 2016Review
- Study of Optimal Replacement of Thyroxine in the Elderly (SORTED) - results from the feasibility randomised controlled trial.Thyroid research · 2016Article
- The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism.European thyroid journal · 2015Article
- Article
- Cardiovascular risk and quality of life in elderly people with mild thyroid hormone deficiency.Frontiers in endocrinology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 5 countries.
Funding
Abstract
backgroundSubclinical thyroid dysfunction is common among older people and has been associated with decreased functional capacity but with conflicting data. The aim of this study was to assess the association between subclinical thyroid dysfunction and functional capacity in an elderly population.
methodsWe included 5182 participants with a mean age of 75.2 years from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Self-reported functional capacity was assessed using the Barthel Index (BI) and the Instrumental Activities of Daily Living (IADL) scores at baseline and during follow-up. Participants with subclinical hyperthyroidism (n=65) and subclinical hypothyroidism (n=173) were compared to euthyroid participants (n=4944). The association between persistent subclinical thyroid dysfunction and functional capacity and decline was also investigated.
resultsAt baseline, compared to euthyroid participants (BI 19.73±SE 0.06; IADL 13.52±0.02), there was no difference in functional capacity for participants with subclinical hyperthyroidism (BI 19.60±0.09; IADL 13.51±0.12, p>0.05) or subclinical hypothyroidism (BI 19.82±0.06; IADL 13.55±0.08, p>0.05). Over a mean 3.2-year follow-up period, there was no association between thyroid function and annual decline of either BI or IADL (p>0.05). No association was found between persistent subclinical thyroid dysfunction and functional capacity at baseline or during follow-up (p>0.05). Results were similar after excluding participants with a maximum BI and/or IADL score at baseline.
conclusionAmong well-functioning community-dwelling elderly, we found no evidence that subclinical thyroid dysfunction contributes to decreased functional capacity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.