ArticleBMC pediatrics2013
Association between interleukin 1β and interleukin 10 concentrations: a cross-sectional study in young adolescents in Taiwan.
Article in BMC pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
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- Sex-specific regulation of IL-10 production in human adipose tissue in obesity.Frontiers in endocrinology · 2022Article
- Utility of Adipokines and IL-10 in Association with Anthropometry in Prediction of Insulin Resistance in Obese Children.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
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- Metabolic control and sex: A focus on inflammatory-linked mediators.British journal of pharmacology · 2019Review
- Hyperglycaemia, oxidative stress and inflammatory markers.Redox report : communications in free radical research · 2017Article
- A review of iron studies in overweight and obese children and adolescents: a double burden in the young?European journal of nutrition · 2016Review
- Serum Ferritin Is Inversely Correlated with Testosterone in Boys and Young Male Adolescents: A Cross-Sectional Study in Taiwan.PloS one · 2015Article
- Serum hepcidin levels and iron metabolism in obese children with and without fatty liver: case-control study.European journal of pediatrics · 2014Article
- THE EFFECT OF AEROBIC TRAINING WITH DIFFERENCE DURATIONS ON SERUM IL-10 IN MIDDLE-AGED OBESE FEMALES.Acta endocrinologica (Bucharest, Romania : 2005)Article
- Evaluation of serum interleukin-10 levels as a predictor of glycemic alteration in chronic periodontitis and type 2 diabetes mellitus.Journal of Indian Society of PeriodontologyArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn adults, low circulating interleukin 10 (IL10) has been associated with obesity and type 2 diabetes. However, studies investigating IL10 in overweight and obese children have yielded conflicting results. The aim of this study was to investigate factors associated with serum IL10 concentration in young Chinese adolescents.
methodsYoung adolescents (n=325) ages 13.33±1.10 years were recruited into the cross-sectional study from 2010 to 2011. Parameters of obesity, individual components of MetS, iron status and serum IL10 were evaluated.
resultsCompared with their normal weight counterparts, overweight adolescents had lower serum IL10 but higher TNFα, nitric oxide (NO) and IL1β concentrations (all p<0.05). Obese adolescents had increased IL1β but decreased hepcidin concentration compared with normal weight (p<0.01 and p<0.05; respectively). A strong inverse relationship (p<0.0001) was found between IL10 and pro-inflammatory cytokines (TNFα and IL1β). Multivariate linear regression analysis showed serum IL1β was significantly correlated with IL10 (β=-0.156, p<0.0001). When overweight and obese adolescents were assessed separately from normal weight, only IL1β was inversely associated with serum IL10 (β=-0.231, p=0.0009). The association between IL10 and IL1β was weaker in adolescents with normal weight (β=-0.157, p=0.0002), after adjusting for gender, TNFα, IFNγ and NO.
conclusionsOur study confirmed that low IL10 concentration is associated with overweight and obesity in young adolescents. We also demonstrated for the first time that pro-inflammatory cytokine IL1β is independently associated with IL10. A decline in IL10 concentration in overweight and obese adolescents may further contribute to the IL1β-mediated inflammatory environment associated with obesity.
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