ArticleBMC veterinary research2013
Identification of neglected cestode Taenia multiceps microRNAs by illumina sequencing and bioinformatic analysis.
Article in BMC veterinary research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Wild birds of Al-Jouf region may harbor zoonotic parasites.Open veterinary journal · 2024Article
- Annexin gene family in Spirometra mansoni (Cestoda: Diphyllobothriidae) and its phylogenetic pattern among Platyhelminthes of medical interest.Parasite (Paris, France) · 2024Article
- Cestodes in the genomic era.Parasitology research · 2022Review
- Taenia solium and Taenia crassiceps: miRNomes of the larvae and effects of miR-10-5p and let-7-5p on murine peritoneal macrophages.Bioscience reports · 2019Article
- Molecular characterisation and expression analysis of two heat-shock proteins in Taenia multiceps.Parasites & vectors · 2019Article
- Article
- The genome of tapeworm Taenia multiceps sheds light on understanding parasitic mechanism and control of coenurosis disease.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- MicroRNAs inFrontiers in microbiology · 2017Review
- microRNA profiling in the zoonotic parasite Echinococcus canadensis using a high-throughput approach.Parasites & vectors · 2015Article
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWorldwide, but especially in developing countries, coenurosis of sheep and other livestock is caused by Taenia multiceps larvae, and zoonotic infections occur in humans. Infections frequently lead to host death, resulting in huge socioeconomic losses. MicroRNAs (miRNAs) have important roles in the post-transcriptional regulation of a large number of animal genes by imperfectly binding target mRNAs. To date, there have been no reports of miRNAs in T. multiceps.
resultsIn this study, we obtained 12.8 million high quality raw reads from adult T. multiceps small RNA library using Illumina sequencing technology. A total of 796 conserved miRNA families (containing 1,006 miRNAs) from 170,888 unique miRNAs were characterized using miRBase (Release 17.0). Here, we selected three conserved miRNA/miRNA* (antisense strand) duplexes at random and amplified their corresponding precursors using a PCR-based method. Furthermore, 20 candidate novel miRNA precursors were verified by genomic PCR. Among these, six corresponding T. multiceps miRNAs are considered specific for Taeniidae because no homologs were found in other species annotated in miRBase. In addition, 181,077 target sites within T. multiceps transcriptome were predicted for 20 candidate newly miRNAs.
conclusionsOur large-scale investigation of miRNAs in adult T. multiceps provides a substantial platform for improving our understanding of the molecular regulation of T. multiceps and other cestodes development.
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