ArticlePloS one2013
Quantitatively increased somatic transposition of transposable elements in Drosophila strains compromised for RNAi.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Persistent viral infection in the Drosophila fat body is associated with immune activation at the single cell level.BMC genomics · 2026Article
- Experimental Approaches to Study Somatic Transposition in Drosophila Using Whole-Genome DNA Sequencing.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Insecticidal RNA interference, thinking beyond long dsRNA.Pest management science · 2021Review
- Article
- Diversification and collapse of a telomere elongation mechanism.Genome research · 2019Article
- Dual-layer transposon repression in heads ofRNA (New York, N.Y.) · 2018Article
- Drosophila melanogaster retrotransposon and inverted repeat-derived endogenous siRNAs are differentially processed in distinct cellular locations.BMC genomics · 2017Article
- Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS.PLoS genetics · 2017Article
- Production of Small Noncoding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster.Genetics · 2016Article
- Article
- Expression of the Retrotransposon Helena Reveals a Complex Pattern of TE Deregulation in Drosophila Hybrids.PloS one · 2016Article
- Antisense Transcription of Retrotransposons in Drosophila: An Origin of Endogenous Small Interfering RNA Precursors.Genetics · 2016Article
- Changes of Osvaldo expression patterns in germline of male hybrids between the species Drosophila buzzatii and Drosophila koepferae.Molecular genetics and genomics : MGG · 2015Article
- Does ectopic cell death cause somatic mutations in the neighboring cells by activating transposons?Mobile genetic elements · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila melanogaster, small RNAs homologous to transposable elements (TEs) are of two types: piRNA (piwi-interacting RNA) with size 23-29nt and siRNA (small interfering RNA) with size 19-22nt. The siRNA pathway is suggested to silence TE activities in somatic tissues based on TE expression profiles, but direct evidence of transposition is lacking. Here we developed an efficient FISH (fluorescence in Situ hybridization) based method for polytene chromosomes from larval salivary glands to reveal new TE insertions. Analysis of the LTR-retrotransposon 297 and the non-LTR retroposon DOC shows that in the argonaut 2 (Ago2) and Dicer 2 (Dcr2) mutant strains, new transposition events are much more frequent than in heterozygous strains or wild type strains. The data demonstrate that the siRNA pathway represses TE transposition in somatic cells. Nevertheless, we found that loss of one functional copy of Ago2 or Dcr2 increases somatic transpositions of the elements at a lower level depending on the genetic background, suggesting a quantitative role for RNAi core components on mutation frequency.
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