ArticlePloS one2013
Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Correction: Phosphorylation of the actin binding protein drebrin at S647 is regulated by neuronal activity and PTEN.PloS one · 2026Article
- Exploring Brain Imaging and Genetic Risk Factors in Different Progression States of Alzheimer's Disease Through OSnetNMF-Based Methods.Journal of molecular neuroscience : MN · 2025Article
- Phosphoprofile reorganization of the actin binding protein Drebrin during long term depression.Frontiers in molecular neuroscience · 2025Article
- Profiling ubiquitin signalling with UBIMAX reveals DNA damage- and SCFNature communications · 2023Article
- Review
- The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex.Scientific reports · 2021Article
- PEBP1/RKIP behavior: a mirror of actin-membrane organization.Cellular and molecular life sciences : CMLS · 2020Article
- Dual-Specific Protein and Lipid Phosphatase PTEN and Its Biological Functions.Cold Spring Harbor perspectives in medicine · 2020Review
- PTEN in Autism and Neurodevelopmental Disorders.Cold Spring Harbor perspectives in medicine · 2019Review
- ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans.Nature communications · 2019Article
- PTEN Inhibition in Human Disease Therapy.Molecules (Basel, Switzerland) · 2018Review
- PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules.PloS one · 2018Article
- Investigation of hippocampal synaptic transmission and plasticity in mice deficient in the actin-binding protein Drebrin.Scientific reports · 2017Article
- Drebrin and Spermatogenesis.Advances in experimental medicine and biology · 2017Article
- Drebrin coordinates the actin and microtubule cytoskeleton during the initiation of axon collateral branches.Developmental neurobiology · 2016Article
- Cytoskeletal social networking in the growth cone: How +TIPs mediate microtubule-actin cross-linking to drive axon outgrowth and guidance.Cytoskeleton (Hoboken, N.J.) · 2016Review
- Organization and dynamics of the actin cytoskeleton during dendritic spine morphological remodeling.Cellular and molecular life sciences : CMLS · 2016Review
- PTEN regulates cilia through Dishevelled.Nature communications · 2015Article
- Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes.Journal of medical genetics · 2015Article
- Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders.Frontiers in molecular neuroscience · 2014Review
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
Defects in actin dynamics affect activity-dependent modulation of synaptic transmission and neuronal plasticity, and can cause cognitive impairment. A salient candidate actin-binding protein linking synaptic dysfunction to cognitive deficits is Drebrin (DBN). However, the specific mode of how DBN is regulated at the central synapse is largely unknown. In this study we identify and characterize the interaction of the PTEN tumor suppressor with DBN. Our results demonstrate that PTEN binds DBN and that this interaction results in the dephosphorylation of a site present in the DBN C-terminus--serine 647. PTEN and pS647-DBN segregate into distinct and complimentary compartments in neurons, supporting the idea that PTEN negatively regulates DBN phosphorylation at this site. We further demonstrate that neuronal activity increases phosphorylation of DBN at S647 in hippocampal neurons in vitro and in ex vivo hippocampus slices exhibiting seizure activity, potentially by inducing rapid dissociation of the PTEN:DBN complex. Our results identify a novel mechanism by which PTEN is required to maintain DBN phosphorylation at dynamic range and signifies an unusual regulation of an actin-binding protein linked to cognitive decline and degenerative conditions at the CNS synapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.