Trial reportPloS one2013
Exercise-induced blood lactate increase does not change red blood cell deformability in cyclists.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Investigating the Hemorheological, Metabolic, and Physical Performance Effect of a Core Muscle Strengthening Training Program.Life (Basel, Switzerland) · 2025Article
- Running on the edge: hematological responses to a non-stop ultramarathon with a focus on nitric oxide-mediated red blood cell deformability.Frontiers in physiology · 2025Article
- Article
- Effect of Whole-Body Vibration Training on Hemorheological Blood Indices in Young, Healthy Women.International journal of environmental research and public health · 2023Article
- Article
- Effects of L-arginine on impaired blood fluidity after high-intensity exercise: An in vitro evaluation.Clinical hemorheology and microcirculation · 2022Article
- Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling.International journal of molecular sciences · 2021Article
- Cerebral tissue pOScientific reports · 2020Article
- Increases in core temperature counterbalance effects of haemoconcentration on blood viscosity during prolonged exercise in the heat.Experimental physiology · 2016Article
- Stiffening of sickle cell trait red blood cells under simulated strenuous exercise conditions.Microsystems & nanoengineering · 2016Article
- Nitric oxide, vasodilation and the red blood cell.Biorheology · 2014Review
- Red blood cells in sports: effects of exercise and training on oxygen supply by red blood cells.Frontiers in physiology · 2013Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effect of exercise-induced lactate production on red blood cell deformability and other blood rheological changes is controversial, given heavy-exercise induces biochemical processes (e.g., oxidative stress) known to perturb haemorheology. The aim of the present study was to examine the haemorheological response to a short-duration cycling protocol designed to increase blood lactate concentration, but of duration insufficient to induce significant oxidative stress.
methodsMale cyclists and triathletes (n = 6; 27±7 yr; body mass index: 23.7±3.0 kg/m²; peak oxygen uptake 4.02±0.51 L/min) performed unloaded (0 W), moderate-intensity, and heavy-intensity cycling. Blood was sampled at rest and during the final minute of each cycling bout. Blood chemistry, blood viscosity, red blood cell aggregation and red blood cell deformability were measured.
resultsBlood lactate concentration increased significantly during heavy-intensity cycling, when compared with all other conditions. Methaemoglobin fraction did not change during any exercise bout when compared with rest. Blood viscosity at native haematocrit increased during heavy-intensity cycling at higher-shear rates when compared with rest, unloaded and moderate-intensity cycling. Heavy-intensity exercise increased the amplitude of red blood cell aggregation in native haematocrit samples when compared with all other conditions. Red blood cell deformability was not changed by exercise.
conclusionAcute exercise perturbs haemorheology in an intensity dose-response fashion; however, many of the haemorheological effects appear to be secondary to haemoconcentration, rather than increased lactate concentration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.