ArticlePloS one2013
Sarcoptes scabiei mites modulate gene expression in human skin equivalents.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Infestation byInternational journal for parasitology. Parasites and wildlife · 2025Article
- FatalJournal of veterinary research · 2024Article
- Genomics reveal local skin immune response key to control sarcoptic mange in Iberian ibex (Capra pyrenaica).BMC genomics · 2024Article
- Scabies vaccines: where we stand and challenges ahead.Parasitology research · 2024Review
- Scabies: Immunopathogenesis and pathological changes.Parasitology research · 2024Review
- The Causal Effect Between Human Microbiota and Scabies: A Study from the Genetic Perspective.Clinical, cosmetic and investigational dermatology · 2024Article
- Egyptian mandarin peel oil's anti-scabies potential via downregulation-of-inflammatory/immune-cross-talk: GC-MS and PPI network studies.Scientific reports · 2023Article
- Artificial Infestation ofInternational journal of molecular sciences · 2023Article
- Commentary: Transcriptome analysis of host inflammatory responses to the ectoparasitic miteFrontiers in immunology · 2023Article
- Scabicidal Potential of Coconut Seed Extract in Rabbits via Downregulating Inflammatory/Immune Cross Talk: A Comprehensive Phytochemical/GC-MS and In Silico Proof.Antibiotics (Basel, Switzerland) · 2022Article
- Molecular detection and characterization ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- Transcriptome Analysis of Host Inflammatory Responses to the Ectoparasitic MiteFrontiers in immunology · 2021Article
- Host-Parasite Interaction inAnimals : an open access journal from MDPI · 2020Article
- Early immune suppression leads to uncontrolled mite proliferation and potent host inflammatory responses in a porcine model of crusted versus ordinary scabies.PLoS neglected tropical diseases · 2020Article
- Effects of Low-level Brodifacoum Exposure on the Feline Immune Response.Scientific reports · 2018Article
- Host immune responses to the itch mite, Sarcoptes scabiei, in humans.Parasites & vectors · 2017Review
- A review of Sarcoptes scabiei: past, present and future.Parasites & vectors · 2017Review
- Identification of antigenic Sarcoptes scabiei proteins for use in a diagnostic test and of non-antigenic proteins that may be immunomodulatory.PLoS neglected tropical diseases · 2017Article
- Sarcoptes scabiei: genomics to proteomics to biology.Parasites & vectors · 2016Article
- A Proteomic Analysis of Sarcoptes scabiei (Acari: Sarcoptidae).Journal of medical entomology · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The ectoparasitic mite, Sarcoptes scabiei that burrows in the epidermis of mammalian skin has a long co-evolution with its hosts. Phenotypic studies show that the mites have the ability to modulate cytokine secretion and expression of cell adhesion molecules in cells of the skin and other cells of the innate and adaptive immune systems that may assist the mites to survive in the skin. The purpose of this study was to identify genes in keratinocytes and fibroblasts in human skin equivalents (HSEs) that changed expression in response to the burrowing of live scabies mites. Overall, of the more than 25,800 genes measured, 189 genes were up-regulated >2-fold in response to scabies mite burrowing while 152 genes were down-regulated to the same degree. HSEs differentially expressed large numbers of genes that were related to host protective responses including those involved in immune response, defense response, cytokine activity, taxis, response to other organisms, and cell adhesion. Genes for the expression of interleukin-1α (IL-1α) precursor, IL-1β, granulocyte/macrophage-colony stimulating factor (GM-CSF) precursor, and G-CSF precursor were up-regulated 2.8- to 7.4-fold, paralleling cytokine secretion profiles. A large number of genes involved in epithelium development and keratinization were also differentially expressed in response to live scabies mites. Thus, these skin cells are directly responding as expected in an inflammatory response to products of the mites and the disruption of the skin's protective barrier caused by burrowing. This suggests that in vivo the interplay among these skin cells and other cell types, including Langerhans cells, dendritic cells, lymphocytes and endothelial cells, is responsible for depressing the host's protective response allowing these mites to survive in the skin.
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