ArticlePloS one2013
Adverse drug events in older hospitalized patients: results and reliability of a comprehensive and structured identification strategy.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Machine learning to predict adverse drug events based on electronic health records: a systematic review and meta-analysis.The Journal of international medical research · 2024Pooled it
- Electronic health record-based prediction models for in-hospital adverse drug event diagnosis or prognosis: a systematic review.Journal of the American Medical Informatics Association : JAMIA · 2023Pooled it
- Mortality among patients due to adverse drug reactions that occur following hospitalisation: a meta-analysis.European journal of clinical pharmacology · 2019Pooled it
- Differences in prescribing errors between electronic prescribing and traditional prescribing among medical students: A randomized pilot study.British journal of clinical pharmacology · 2025Trial
- Adverse drug events during transitions of care : Randomized clinical trial of medication reconciliation at hospital admission.Wiener klinische Wochenschrift · 2022Trial
- Reduction in targeted potentially inappropriate medication use in elderly inpatients: a pragmatic randomized controlled trial.European journal of clinical pharmacology · 2017Trial
- Detection of Adverse Medicine Events by Pharmacists in Residential Aged Care Facilities: Secondary Analysis of Data From ReMInDAR Trial.Pharmacoepidemiology and drug safety · 2025Article
- Article
- An innovative method to strengthen evidence for potential drug safety signals using Electronic Health Records.Journal of medical systems · 2024Article
- Drug Related Problems among Older Inpatients at a Tertiary Care Setting.Journal of clinical medicine · 2024Article
- Adverse drug event detection using natural language processing: A scoping review of supervised learning methods.PloS one · 2023Article
- Automatic Detection of Adverse Drug Events in Geriatric Care: Study Proposal.JMIR research protocols · 2022Article
- Turning evidence into action using a senior friendly hospital framework and a collaborative network.Healthcare management forum · 2022Article
- Article
- Clinical validation of clinical decision support systems for medication review: A scoping review.British journal of clinical pharmacology · 2022Article
- Drug-Related Hospital AdmissionsFrontiers in pharmacology · 2022Article
- Prevalence and predictors of medication-related emergency department visit in older adults: A multicenter study linking national claim database and hospital medical records.Frontiers in pharmacology · 2022Article
- STOPP-START Medication Review: A Non-Randomized Trial in an Indonesian Tertiary Hospital to Improve Medication Appropriateness and to Reduce the Length of Stay of Older Adults.Hospital pharmacy · 2021Article
- Utility of a trigger tool (TRIGGER-CHRON) to detect adverse events associated with high-alert medications in patients with multimorbidity.European journal of hospital pharmacy : science and practice · 2021Observational
- Observational
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOlder patients are at high risk for experiencing Adverse Drug Events (ADEs) during hospitalization. To be able to reduce ADEs in these vulnerable patients, hospitals first need to measure the occurrence of ADEs, especially those that are preventable. However, data on preventable ADEs (pADEs) occurring during hospitalization in older patients are scarce, and no 'gold standard' for the identification of ADEs exists. METHODOLOGY: The study was conducted in three hospitals in the Netherlands in 2007. ADEs were retrospectively identified by a team of experts using a comprehensive and structured patient chart review (PCR) combined with a trigger-tool as an aid. This ADE identification strategy was applied to a cohort of 250 older hospitalized patients. To estimate the intra- and inter-rater reliabilities, Cohen's kappa values were calculated. PRINCIPAL
findingsIn total, 118 ADEs were detected which occurred in 62 patients. This ADE yield was 1.1 to 2.7 times higher in comparison to other ADE studies in older hospitalized patients. Of the 118 ADEs, 83 (70.3%) were pADEs; 51 pADEs (43.2% of all ADEs identified) caused serious patient harm. Patient harm caused by ADEs resulted in various events. The overall intra-rater agreement of the developed strategy was substantial (κ = 0.74); the overall inter-rater agreement was only fair (κ = 0.24). CONCLUSIONS/SIGNIFICANCE: The ADE identification strategy provided a detailed insight into the scope of ADEs occurring in older hospitalized patients, and showed that the majority of (serious) ADEs can be prevented. Several strategy related aspects, as well as setting/study specific aspects, may have contributed to the results gained. These aspects should be considered whenever ADE measurements need to be conducted. The results regarding pADEs can be used to design tailored interventions to effectively reduce harm caused by medication errors. Improvement of the inter-rater reliability of a PCR remains challenging.
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