ArticlePloS one2013
Elderly men have low levels of anti-Müllerian hormone and inhibin B, but with high interpersonal variation: a cross-sectional study of the sertoli cell hormones in 615 community-dwelling men.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Anti-Müllerian Hormone as a Marker for Castration Status and Fertility in Bulls and Oxen.Reproduction in domestic animals = Zuchthygiene · 2026Article
- Effects of High-dose Radioactive Iodine Therapy on Hormonal Profiles and Sperm Quality in Thyroidectomy Patients.Molecular imaging and radionuclide therapy · 2026Article
- Reduced anti-Müllerian hormone levels in males with inherited bone marrow failure syndromes.Endocrine connections · 2024Article
- Endocrine and dog factors associated with semen quality.Scientific reports · 2024Article
- Anti-Müllerian hormone as a diagnostic marker for testicular degeneration in dogs: insights from cryptorchid models.Frontiers in veterinary science · 2024Article
- Sex-biased TGFβ signalling in pulmonary arterial hypertension.Cardiovascular research · 2023Review
- Anti-Müllerian hormone concentration is associated with central adiposity and reproductive hormones in expectant fathers.Clinical endocrinology · 2022Article
- Occupational Health Aspects with Special Focus on Physiological Differences between Office and Metalworkers.Antioxidants (Basel, Switzerland) · 2022Article
- Anti-mullerian hormone attenuates insulin resistance and systemic inflammation in old obese C57BL/6 male mice.Journal of diabetes and metabolic disorders · 2021Article
- Clinical Applications of Serum Anti-Müllerian Hormone Measurements in Both Males and Females: An Update.Innovation (Cambridge (Mass.)) · 2021Review
- Immunohistochemical characterization of the anti-Müllerian hormone receptor type 2 (AMHR-2) in human testes.Endocrine · 2020Article
- Association of Anti-Mullerian Hormone with C-Reactive Protein in Men.Scientific reports · 2019Article
- Anti-Müllerian Hormone Levels and Cardiometabolic Disturbances by Weight Status Among Men in the 1999 to 2004 National Health and Nutrition Examination Survey.Journal of the Endocrine Society · 2019Article
- A novel, noncoding-RNA-mediated, post-transcriptional mechanism of anti-Mullerian hormone regulation by the H19/let-7 axis.Biology of reproduction · 2019Article
- Premature ovarian aging inOncotarget · 2018Article
- Associations between Urinary Phthalate Metabolites and Serum Anti-Müller Hormone Levels in U.S. Men Based on National Health and Nutrition Examination Survey 2003-2004.International journal of environmental research and public health · 2017Article
- Anti-Müllerian Hormone Levels in Preeclampsia: A Systematic Review of the Literature.Journal of family & reproductive health · 2017Review
- Serum variations of anti-mullerian hormone and total testosterone with aging in healthy adult Iranian men: A population-based study.PloS one · 2017Article
- Serum anti-mullerian hormone and all-cause mortality in men.Endocrine · 2016Article
- Relative levels of the proprotein and cleavage-activated form of circulating human anti-Müllerian hormone are sexually dimorphic and variable during the life cycle.Physiological reports · 2016Article
Corrections and comments
- Erratum issuedMlennan, Ian S [corrected to McLennan, Ian S]
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Sertoli cells of the testes secrete anti-Müllerian hormone (Müllerian inhibiting Substance, AMH) and inhibin B (InhB). AMH triggers the degeneration of the uterine precursor in male embryos, whereas InhB is part of the gonadal-pituitary axis for the regulation of sperm production in adults. However, both hormones are also putative regulators of homeostasis, and age-related changes in these hormones may therefore be important to the health status of elderly men. The levels of AMH in elderly men are unknown, with limited information being available about age-related changes in InhB. We have therefore used ELISAs to measure Sertoli cell hormone levels in 3 cohorts of community-dwelling men in New Zealand. In total, 615 men were examined, 493 of which were aged 65 or older. Serum AMH and InhB levels inversely correlated with age in men older than 50 years (p<0.001) but not in the younger men. A minority of elderly men had undetectable levels of AMH and InhB. The variation in hormone levels between similarly aged men increased with the age of men. AMH and InhB partially correlated with each other as expected (r = 0.48, p<0.001). However, the ratio of the two Sertoli hormones varied significantly between men, with this variation increasing with age. Elderly men selected for the absence of cardiovascular disease had AMH levels similar to those of young men whereas their InhB levels did not differ from aged-matched controls. These data suggests that Sertoli cell number and function changes with age, but with the extent and nature of the changes varying between men.
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