ArticlePloS one2013
Metabolomics reveals the heterogeneous secretome of two entomopathogenic fungi to ex vivo cultured insect tissues.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
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- Laboratory evaluation of Beauveria bassiana strain ATCC74040 as a potential biocontrol agent of Aculops lycopersici.Scientific reports · 2025Article
- Pathogenicity of the Entomopathogenic Fungus Metarhizium anisopliae s.l. (Ascomycota: Hypocreales) Against Sweetpotato Weevil (Cylas formicarius, Coleoptera: Brentidae) Under In Vitro Conditions.Neotropical entomology · 2025Article
- Visualizing Oral Infection Dynamics ofJournal of fungi (Basel, Switzerland) · 2025Article
- Overlapping and specific bacterial communities in the gut and reproductive system ofFrontiers in microbiology · 2025Article
- The role of insect gut microbiota in host fitness, detoxification and nutrient supplementation.Antonie van Leeuwenhoek · 2024Review
- Volatile Fingerprint Mediates Yeast-to-Mycelial Conversion in Two Strains ofJournal of fungi (Basel, Switzerland) · 2023Article
- Metabolomics Analysis of Sporulation-Associated Metabolites ofJournal of fungi (Basel, Switzerland) · 2023Article
- Effects of passages through an insect or a plant on virulence and physiological properties of the fungusPeerJ · 2023Article
- Biopesticides as a promising alternative to synthetic pesticides: A case for microbial pesticides, phytopesticides, and nanobiopesticides.Frontiers in microbiology · 2023Review
- Isolation and identification of two Beauveria bassiana strains from silkworm, Bombyx mori.Folia microbiologica · 2022Article
- The Entomopathogenic FungusJournal of fungi (Basel, Switzerland) · 2022Review
- The Chemical Ecology Approach to Reveal Fungal Metabolites for Arthropod Pest Management.Microorganisms · 2021Review
- Cordycepin, a metabolite of Cordyceps militaris, reduces immune-related gene expression in insects.Journal of invertebrate pathology · 2020Article
- Tryptamine accumulation caused by deletion of MrMao-1 in Metarhizium genome significantly enhances insecticidal virulence.PLoS genetics · 2020Article
- Secretomic analysis of Beauveria bassiana related to cattle tick, Rhipicephalus microplus, infection.Folia microbiologica · 2019Article
- Three-dimensional visualization and a deep-learning model reveal complex fungal parasite networks in behaviorally manipulated ants.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Metabolic Signatures in Response to Abscisic Acid (ABA) Treatment in Brassica napus Guard Cells Revealed by Metabolomics.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungal entomopathogens rely on cellular heterogeneity during the different stages of insect host infection. Their pathogenicity is exhibited through the secretion of secondary metabolites, which implies that the infection life history of this group of environmentally important fungi can be revealed using metabolomics. Here metabolomic analysis in combination with ex vivo insect tissue culturing shows that two generalist isolates of the genus Metarhizium and Beauveria, commonly used as biological pesticides, employ significantly different arrays of secondary metabolites during infectious and saprophytic growth. It also reveals that both fungi exhibit tissue specific strategies by a distinguishable metabolite secretion on the insect tissues tested in this study. In addition to showing the important heterogeneous nature of these two entomopathogens, this study also resulted in the discovery of several novel destruxins and beauverolides that have not been described before, most likely because previous surveys did not use insect tissues as a culturing system. While Beauveria secreted these cyclic depsipeptides when encountering live insect tissues, Metarhizium employed them primarily on dead tissue. This implies that, while these fungi employ comparable strategies when it comes to entomopathogenesis, there are most certainly significant differences at the molecular level that deserve to be studied.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.