ArticleThe Journal of physiology2013
Modulation of synaptic depression of the calyx of Held synapse by GABA(B) receptors and spontaneous activity.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- High calcium concentrations reduce cellular excitability of mouse MNTB neurons.Brain research · 2023Article
- The role of GABAFrontiers in endocrinology · 2023Review
- Extracellular Signal-Regulated Kinases Mediate an Autoregulation of GABAScientific reports · 2020Article
- Dynamics of synaptic extracellular field potentials in the nucleus laminaris of the barn owl.Journal of neurophysiology · 2019Article
- High Entrainment Constrains Synaptic Depression Levels of anFrontiers in computational neuroscience · 2017Article
- Enhanced Transmission at the Calyx of Held Synapse in a Mouse Model for Angelman Syndrome.Frontiers in cellular neuroscience · 2017Article
- Superpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Evaluation of Drug Concentrations Delivered by Microiontophoresis.Analytical chemistry · 2016Article
- A Well-Defined Readily Releasable Pool with Fixed Capacity for Storing Vesicles at Calyx of Held.PLoS computational biology · 2016Article
- Molecular Machines Regulating the Release Probability of Synaptic Vesicles at the Active Zone.Frontiers in synaptic neuroscience · 2016Review
- Skipped-stimulus approach reveals that short-term plasticity dominates synaptic strength during ongoing activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndrome.Frontiers in cellular neuroscience · 2015Article
- GABAB receptor-mediated tonic inhibition regulates the spontaneous firing of locus coeruleus neurons in developing rats and in citalopram-treated rats.The Journal of physiology · 2015Article
- Synaptic gain-of-function effects of mutant Cav2.1 channels in a mouse model of familial hemiplegic migraine are due to increased basal [Ca2+]i.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The calyx of Held synapse of the medial nucleus of the trapezoid body is a giant axosomatic synapse in the auditory brainstem, which acts as a relay synapse showing little dependence of its synaptic strength on firing frequency. The main mechanism that is responsible for its resistance to synaptic depression is its large number of release sites with low release probability. Here, we investigated the contribution of presynaptic GABA(B) receptors and spontaneous activity to release probability both in vivo and in vitro in young-adult mice. Maximal activation of presynaptic GABA(B) receptors by baclofen reduced synaptic output by about 45% in whole-cell voltage clamp slice recordings, which was accompanied by a reduction in short-term depression. A similar reduction in transmission was observed when baclofen was applied in vivo by microiontophoresis during juxtacellular recordings using piggyback electrodes. No significant change in synaptic transmission was observed during application of the GABA(B) receptor antagonist CGP54626 both during in vivo and slice recordings, suggesting a low ambient GABA concentration. Interestingly, we observed that synapses with a high spontaneous frequency showed almost no synaptic depression during auditory stimulation, whereas synapses with a low spontaneous frequency did depress during noise bursts. Our data thus suggest that spontaneous firing can tonically reduce release probability in vivo. In addition, our data show that the ambient GABA concentration in the auditory brainstem is too low to activate the GABA(B) receptor at the calyx of Held significantly, but that activation of GABA(B) receptors can reduce sound-evoked synaptic depression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.