ArticleProceedings of the National Academy of Sciences of the United States of America2013
Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Alcohol decreases baseline brain glucose metabolism more in heavy drinkers than controls but has no effect on stimulation-induced metabolic increases.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Trial
- Reversible alterations of brain acetate metabolism associated with alcohol consumption.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Nrf2 activator peptide protects the brain from cerebral vascular dysfunction in alcohol ingestion.JCI insight · 2026Article
- A Low-Stress, Long-Duration Stable Tail Vein Catheterization and Precise Drug Delivery Protocol for Awake, Freely Moving Mice.Bio-protocol · 2026Article
- Chronic alcohol consumption downregulates TRPA1 ion channel and the main peptidergic messengers of the Edinger-Westphal nucleus.Scientific reports · 2025Article
- Naltrexone Alters Neurochemical and Behavioral Parameters in a Zebrafish Model of Repeated Alcohol Exposure.Neurochemical research · 2025Article
- Alcohol spiked with zolpidem and midazolam potentiates inflammation, oxidative stress and organ damage in a mouse model.Forensic toxicology · 2024Article
- Ketogenic diet reduces a neurobiological craving signature in inpatients with alcohol use disorder.Frontiers in nutrition · 2024Article
- Differential Effects of Chronic Ethanol Use on Mouse Neuronal and Astroglial Metabolic Activity.Neurochemical research · 2023Article
- [Establishment and behavioral evaluation of a mouse model of long-term free-choice alcohol drinking].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Ethanol Metabolite, Acetate, Increases Excitability of the Central Nucleus of Amygdala Neurons through Activation of NMDA Receptors.ACS chemical neuroscience · 2023Article
- Brain ethanol metabolism and mitochondria.Current topics in biochemical research · 2022Article
- Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents.Science advances · 2021Article
- The ethanol metabolite acetic acid activates mouse nucleus accumbens shell medium spiny neurons.Journal of neurophysiology · 2021Article
- Article
- Regional Metabolic Patterns of Abnormal Postoperative Behavioral Performance in Aged Mice Assessed byNeuroscience bulletin · 2020Article
- Correspondence between cerebral glucose metabolism and BOLD reveals relative power and cost in human brain.Nature communications · 2019Article
- Acetate Mediates Alcohol Excitotoxicity in Dopaminergic-like PC12 Cells.ACS chemical neuroscience · 2019Article
- Altered brain activity during withdrawal from chronic alcohol is associated with changes in IL-6 signal transduction and GABAergic mechanisms in transgenic mice with increased astrocyte expression of IL-6.Neuropharmacology · 2018Article
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
It has been reported that chronic and acute alcohol exposure decreases cerebral glucose metabolism and increases acetate oxidation. However, it remains unknown how much ethanol the living brain can oxidize directly and whether such a process would be affected by alcohol exposure. The questions have implications for reward, oxidative damage, and long-term adaptation to drinking. One group of adult male Sprague-Dawley rats was treated with ethanol vapor and the other given room air. After 3 wk the rats received i.v. [2-(13)C]ethanol and [1, 2-(13)C2]acetate for 2 h, and then the brain was fixed, removed, and divided into neocortex and subcortical tissues for measurement of (13)C isotopic labeling of glutamate and glutamine by magnetic resonance spectroscopy. Ethanol oxidation was seen to occur both in the cortex and the subcortex. In ethanol-naïve rats, cortical oxidation of ethanol occurred at rates of 0.017 ± 0.002 µmol/min/g in astroglia and 0.014 ± 0.003 µmol/min/g in neurons, and chronic alcohol exposure increased the astroglial ethanol oxidation to 0.028 ± 0.002 µmol/min/g (P = 0.001) with an insignificant effect on neuronal ethanol oxidation. Compared with published rates of overall oxidative metabolism in astroglia and neurons, ethanol provided 12.3 ± 1.4% of cortical astroglial oxidation in ethanol-naïve rats and 20.2 ± 1.5% in ethanol-treated rats. For cortical astroglia and neurons combined, the ethanol oxidation for naïve and treated rats was 3.2 ± 0.3% and 3.8 ± 0.2% of total oxidation, respectively. (13)C labeling from subcortical oxidation of ethanol was similar to that seen in cortex but was not affected by chronic ethanol exposure.
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Registered trials
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