ArticleProceedings of the National Academy of Sciences of the United States of America2013
Transient, afferent input-dependent, postnatal niche for neural progenitor cells in the cochlear nucleus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Neurogenic Stem Cell Niche in the Auditory Thalamus: In Vitro Evidence of Neural Stem Cells in the Rat Medial Geniculate Body.Life (Basel, Switzerland) · 2023Article
- In Vitro Culturing of Adult Stem Cells: The Importance of Serum and Atmospheric Oxygen.Advances in experimental medicine and biology · 2022Review
- Article
- Evaluation of the Neurogenic Potential in the Rat Inferior Colliculus from Early Postnatal Days Until Adulthood.Molecular neurobiology · 2021Article
- Different Neurogenic Potential in the Subnuclei of the Postnatal Rat Cochlear Nucleus.Stem cells international · 2021Article
- Isolation and Characterization of Neural Stem Cells from the Rat Inferior Colliculus.Stem cells international · 2019Article
- Review
- Review
- Paracrine Wnt/β-catenin signaling mediates proliferation of undifferentiated spermatogonia in the adult mouse testis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Culture and properties of adipose-derived mesenchymal stem cells: characteristics in vitro and immunosuppression in vivo.International journal of clinical and experimental pathology · 2015Article
- Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Spiral ganglion stem cells can be propagated and differentiated into neurons and glia.BioResearch open access · 2014Article
Corrections and comments
- Erratum issuedvan Amerongen, Renée [added]
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
In the cochlear nucleus (CN), the first central relay of the auditory pathway, the survival of neurons during the first weeks after birth depends on afferent innervation from the cochlea. Although input-dependent neuron survival has been extensively studied in the CN, neurogenesis has not been evaluated as a possible mechanism of postnatal plasticity. Here we show that new neurons are born in the CN during the critical period of postnatal plasticity. Coincidently, we found a population of neural progenitor cells that are controlled by a complex interplay of Wnt, Notch, and TGFβ/BMP signaling, in which low levels of TGFβ/BMP signaling are permissive for progenitor proliferation that is promoted by Wnt and Notch activation. We further show that cells with activated Wnt signaling reside in the CN and that these cells have high propensity for neurosphere formation. Cochlear ablation resulted in diminishment of progenitors and Wnt/β-catenin-active cells, suggesting that the neonatal CN maintains an afferent innervation-dependent population of progenitor cells that display active canonical Wnt signaling.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.