ArticleProceedings of the National Academy of Sciences of the United States of America2013
Availability of public goods shapes the evolution of competing metabolic strategies.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed.
- The protease code of the bacterial gut microbiota: ecological regulation, barrier disruption, and rewiring host defense and signaling.Gut microbes · 2026Review
- Challenging the paradigm of metabolic exclusivity: coexistence of methanogenesis and sulfate reduction in oil reservoirs.Applied and environmental microbiology · 2026Article
- The effect of substrate and product transfer between polydisperse microdroplets on biological high-throughput screens.Scientific reports · 2026Article
- Alkaline pH-Driven Metabolic Plasticity of Lactococcus lactis FM03.Environmental microbiology · 2025Article
- Inheritance of extraordinary metabolic activity from parental bacteria individuals.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Trait and plasticity evolution under competition and mutualism in evolving pairwise yeast communities.PloS one · 2025Article
- Nutrient colimitation is a quantitative, dynamic property of microbial populations.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- High cell density cultivation by anaerobic respiration.Microbial cell factories · 2024Article
- Mitochondrial ATP generation is more proteome efficient than glycolysis.Nature chemical biology · 2024Article
- Bioenergetic characterization of hyperthermophilic archaean Methanocaldococcus sp. FS406-22.Extremophiles : life under extreme conditions · 2024Article
- Serial cultures in invert emulsion and monophase systems for microbial community shaping and propagation.Microbial cell factories · 2024Article
- Genetic evidence for algal auxin production iniScience · 2024Article
- Evolution and screening of Trichoderma reesei mutants for secreted protein production at elevated temperature.Journal of industrial microbiology & biotechnology · 2024Article
- Methyl halide transferase-based gas reporters for quantification of filamentous bacteria in microdroplet emulsions.Applied and environmental microbiology · 2023Article
- High-throughput process development from gene cloning to protein production.Microbial cell factories · 2023Review
- The evolutionary ecology of fungal killer phenotypes.Proceedings. Biological sciences · 2023Review
- Double emulsions as a high-throughput enrichment and isolation platform for slower-growing microbes.ISME communications · 2023Article
- Indirect Enrichment of Desirable, but Less Fit Phenotypes, from a Synthetic Microbial Community Using Microdroplet Confinement.ACS synthetic biology · 2023Article
- Invert emulsions alleviate biotic interactions in bacterial mixed culture.Microbial cell factories · 2023Article
- Indirect enrichment of desirable, but less fit phenotypes, from a synthetic microbial community using microdroplet confinement.bioRxiv : the preprint server for biology · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tradeoffs provide a rationale for the outcome of natural selection. A prominent example is the negative correlation between the growth rate and the biomass yield in unicellular organisms. This tradeoff leads to a dilemma, where the optimization of growth rate is advantageous for an individual, whereas the optimization of the biomass yield would be advantageous for a population. High-rate strategies are observed in a broad variety of organisms such as Escherichia coli, yeast, and cancer cells. Growth in suspension cultures favors fast-growing organisms, whereas spatial structure is of importance for the evolution of high-yield strategies. Despite this realization, experimental methods to directly select for increased yield are lacking. We here show that the serial propagation of a microbial population in a water-in-oil emulsion allows selection of strains with increased biomass yield. The propagation in emulsion creates a spatially structured environment where the growth-limiting substrate is privatized for populations founded by individual cells. Experimental evolution of several isogenic Lactococcus lactis strains demonstrated the existence of a tradeoff between growth rate and biomass yield as an apparent Pareto front. The underlying mutations altered glucose transport and led to major shifts between homofermentative and heterofermentative metabolism, accounting for the changes in metabolic efficiency. The results demonstrated the impact of privatizing a public good on the evolutionary outcome between competing metabolic strategies. The presented approach allows the investigation of fundamental questions in biology such as the evolution of cooperation, cell-cell interactions, and the relationships between environmental and metabolic constraints.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.