ArticleProceedings of the National Academy of Sciences of the United States of America2013
Competing molecular interactions of aPKC isoforms regulate neuronal polarity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- aPKC-ζ III promotes trophoblast fusion by altering Par-3 interactions with Hippo signaling kinase LATS1.Stem cell reports · 2026Article
- PKM ζ-PKC ι / λ double-knockout demonstrates atypical PKC is crucial for the persistence of hippocampal LTP and spatial memory.bioRxiv : the preprint server for biology · 2026Article
- EVL and MIM/MTSS1 regulate actin cytoskeletal remodeling to promote dendritic filopodia in neurons.The Journal of cell biology · 2023Article
- DNA methylation of the promoter region at the CREB1 binding site is a mechanism for the epigenetic regulation of brain-specific PKMζ.Biochimica et biophysica acta. Gene regulatory mechanisms · 2023Article
- The Roles of Par3, Par6, and aPKC Polarity Proteins in Normal Neurodevelopment and in Neurodegenerative and Neuropsychiatric Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Review
- The Onset of Whole-Body Regeneration inFrontiers in cell and developmental biology · 2022Article
- Altered Expression of Par3, aPKC-λ, and Lgl1 in Hippocampus in Kainic Acid-Induced Status Epilepticus Rat Model.Frontiers in neurology · 2021Article
- The roles of atypical protein kinase Cs (aPKCs) in the nervous system: targets for neuroregeneration?Neural regeneration research · 2020Article
- aPKC in neuronal differentiation, maturation and function.Neuronal signaling · 2019Review
- PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization.Cellular and molecular life sciences : CMLS · 2018Review
- Rabs set the stage for polarity.Small GTPases · 2018Review
- Article
- TNF-α stimulates endothelial palmitic acid transcytosis and promotes insulin resistance.Scientific reports · 2017Article
- Cell Polarity in Cerebral Cortex Development-Cellular Architecture Shaped by Biochemical Networks.Frontiers in cellular neuroscience · 2017Review
- Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice.eLife · 2016Article
- PKMζ, but not PKCλ, is rapidly synthesized and degraded at the neuronal synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Homolog of protein kinase Mζ maintains context aversive memory and underlying long-term facilitation in terrestrial snail Helix.Frontiers in cellular neuroscience · 2015Article
- Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma.Science signaling · 2014Article
- Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese Population.Prostate cancer · 2014Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Atypical protein kinase C (aPKC) isoforms ζ and λ interact with polarity complex protein Par3 and are evolutionarily conserved regulators of cell polarity. Prkcz encodes aPKC-ζ and PKM-ζ, a truncated, neuron-specific alternative transcript, and Prkcl encodes aPKC-λ. Here we show that, in embryonic hippocampal neurons, two aPKC isoforms, aPKC-λ and PKM-ζ, are expressed. The localization of these isoforms is spatially distinct in a polarized neuron. aPKC-λ, as well as Par3, localizes at the presumptive axon, whereas PKM-ζ and Par3 are distributed at non-axon-forming neurites. PKM-ζ competes with aPKC-λ for binding to Par3 and disrupts the aPKC-λ-Par3 complex. Silencing of PKM-ζ or overexpression of aPKC-λ in hippocampal neurons alters neuronal polarity, resulting in neurons with supernumerary axons. In contrast, the overexpression of PKM-ζ prevents axon specification. Our studies suggest a molecular model wherein mutually antagonistic intermolecular competition between aPKC isoforms directs the establishment of neuronal polarity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.