ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2013
Detection of obstructive coronary artery disease using regadenoson stress and 82Rb PET/CT myocardial perfusion imaging.
Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Construction and validation of a diagnostic model for obstructive coronary artery disease in patients with suspected unstable angina pectoris based on restingQuantitative imaging in medicine and surgery · 2026Article
- Cardiac Positron Emission Tomography Myocardial Perfusion Imaging: Seeing Beyond Perfusion.World journal of nuclear medicine · 2026Review
- Left ventricular ejection fraction reserve and its association with myocardial perfusion, coronary calcification, and strain in type 2 diabetes without overt cardiovascular disease.Cardiovascular diabetology · 2025Article
- Improved diagnostic accuracy for coronary artery disease detection with quantitative 3DEuropean journal of nuclear medicine and molecular imaging · 2023Article
- Improved Performance of PET Myocardial Perfusion Imaging Compared to SPECT in the Evaluation of Suspected CAD.Current cardiology reports · 2023Review
- Left ventricular ejection fraction, myocardial blood flow and hemodynamic variables in adenosine and regadenoson vasodilator 82-Rubidium PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Imaging Coronary Allograft Vasculopathy with Cardiac PET and Cardiac MRI.Current cardiology reports · 2021Review
- Changes in left ventricle myocardial volume during stress test using cadmium-zinc-telluride cardiac imaging: Implications in coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Impact of regadenoson-induced myocardial creep on dynamic Rubidium-82 PET myocardial blood flow quantification.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Safer stress tests for myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Cardiac-gated parametric images fromMedical physics · 2018Article
- Coronary Microvascular Dysfunction Identifies Patients at High Risk of Adverse Events Across Cardiometabolic Diseases.Journal of the American College of Cardiology · 2017Article
- Rb-82 PET/CT left ventricular mass-to-volume ratios.The international journal of cardiovascular imaging · 2017Article
- Interpreting the change in left ventricular ejection fraction during pharmacological coronary vasodilation: Proceed with caution!Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Clinical value of hyperemic left ventricular systolic function in vasodilator stress testing.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Review
- Left ventricular function in response to dipyridamole stress: head-to-head comparison betweenEuropean journal of nuclear medicine and molecular imaging · 2017Article
- Combined assessment of myocardial perfusion and left ventricular function by nuclear cardiology: The value of high-efficiency SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Quantitation of left ventricular ejection fraction reserve from early gated regadenoson stress Tc-99m high-efficiency SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Clinical use of quantitative cardiac perfusion PET: rationale, modalities and possible indications. Position paper of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM).European journal of nuclear medicine and molecular imaging · 2016Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledOur objective was to study the diagnostic performance of regadenoson (82)Rb myocardial perfusion PET imaging to detect obstructive coronary artery disease (CAD).
methodsWe studied 134 patients (mean age, 63 ± 12 y; mean body mass index, 31 ± 9 kg/m(2)) without known CAD (96 with coronary angiography and 38 with low pretest likelihood of CAD). Stress left ventricular ejection fraction (LVEF) minus rest LVEF defined LVEF reserve. The Duke score was used to estimate the anatomic extent of jeopardized myocardium.
resultsRegadenoson PET had a high sensitivity, 92% (95% confidence interval [CI], 83%-97%), in detecting obstructive CAD, with a normalcy rate of 97% (95% CI, 86%-99%), specificity of 77% (54/70 patients; 95% CI, 66%-86%), and area under the receiver-operator-characteristic curve of 0.847 (95% CI, 0.774-0.903; P < 0.001). Regadenoson PET demonstrated high sensitivity to detect CAD in patients with single-vessel CAD (89%; 95% CI, 70%-98%). The mean LVEF reserve was significantly higher in patients with normal myocardial perfusion imaging results (6.5% ± 5.4%) than in those with mild (4.3 ± 5.1, P = 0.03) and moderate to severe reversible defects (-0.2% ± 8.4%, P = 0.001). Also, mean LVEF reserve was significantly higher in patients with a low likelihood of CAD (7.2% ± 4.5%, P < 0.0001) and mild or moderate jeopardized myocardium than in those with significant jeopardized myocardium (score ≥ 6), -2.8% ± 8.3%.
conclusionRegadenoson (82)Rb myocardial perfusion imaging is accurate for the detection of obstructive CAD. LVEF reserve is high in patients without significant ischemia or significant angiographic jeopardized myocardium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.