ArticleBlood2013
Pivotal role of HIV and EBV replication in the long-term persistence of monoclonal gammopathy in patients on antiretroviral therapy.
Article in Blood, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Increased Epstein-Barr virus in breast milk occurs with subclinical mastitis and HIV shedding.Medicine · 2016Trial
- MGUS in Black individuals in Soweto, South Africa screened by mass spectrometry: results of the PROMISE South Africa study.EClinicalMedicine · 2026Article
- Gamma globulin combined with acyclovir for children with infectious mononucleosis and their effect on immune function.American journal of translational research · 2023Article
- Prevalence of monoclonal gammopathy of undetermined significance (MGUS) at HIV diagnosis in individuals 18-40 years old: a possible HIV indicator condition.Blood cancer journal · 2021Article
- Evaluation of several serum interleukins as markers for treatment effectiveness in naïve HIV infected patients: A pilot study.PloS one · 2021Observational
- Nodular pulmonary deposition disease in a patient with the acquired immunodeficiency syndrome: a case report.Journal of medical case reports · 2020Article
- CD8Frontiers in immunology · 2019Review
- EBV-dUTPase Modulates Host Immune Responses Potentially Altering the Tumor Microenvironment in EBV-associated Malignancies.Current research on HIV/AIDS · 2016Article
- HIV, EBV, and monoclonal gammopathy.Blood · 2013Article
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14 authors at 4 institutions in 2 countries.
Funding
Abstract
A high prevalence of monoclonal gammopathy (MG) has been observed in HIV-infected patients. We explored the conditions associated with long-term persistence of serum monoclonal protein (M protein) in HIV-infected patients on antiretroviral therapy (ART). Of 21 patients with MG, M protein disappeared in 12 patients (58%) over 5 years of ART. Higher level of serum γ-globulin and higher percentages of circulating plasmablasts and plasma cells were observed in patients with persistent MG compared with patients with transient MG. MG persistence was associated with the cumulative time of detectable plasma HIV RNA after ART initiation, detection of Epstein-Barr virus (EBV) DNA in plasma, and a high level of EBV DNA in B cells. Poor control of HIV replication and detectable EBV replication in plasma were both associated with long-term MG persistence in patients on ART. In the case of viral control, MG associated with HIV infection is usually transient.
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