ArticleThe Journal of experimental medicine2013
Multicolor fate mapping of Langerhans cell homeostasis.
Article in The Journal of experimental medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed, 141 citations in OpenAlex.
- Distinct postnatal trajectories of mouse dendritic epidermal T cells and Langerhans cells independent of microbiota.Science advances · 2026Article
- Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dual lineages of Langerhans cells cooperate to restore the immune barrier after skin injury.bioRxiv : the preprint server for biology · 2026Article
- CSF1R regulates monocyte subset differentiation and intracellular metabolism.Nature communications · 2026Article
- Intensity modulation of trichromatic split fluorescent proteins for live cell mapping.Cell reports methods · 2026Article
- Cutaneous Dendritic Cells: Structure, Function and Immune Role.Biomedicines · 2026Review
- CoSiDeX: A hyperspectral fluorescent protein resource for highly multiplexed imaging.bioRxiv : the preprint server for biology · 2025Article
- Epidermal maintenance of Langerhans cells relies on autophagy-regulated lipid metabolism.The Journal of cell biology · 2025Article
- Monocytes give rise to Langerhans cells that preferentially migrate to lymph nodes at steady state.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity.Science immunology · 2024Article
- Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta.Nature communications · 2024Article
- Article
- Tissue-resident macrophages specifically express Lactotransferrin and Vegfc during ear pinna regeneration in spiny mice.Developmental cell · 2024Article
- Fate-Mapping Macrophages: From Ontogeny to Functions.Methods in molecular biology (Clifton, N.J.) · 2024Review
- DNA Barcoding Technology for Lineage Recording and Tracing to Resolve Cell Fate Determination.Cells · 2023Review
- Article
- Proliferation of monocytes and macrophages in homeostasis, infection, injury, and disease.Journal of leukocyte biology · 2023Review
- Metabolic adaption of mucosal macrophages: Is metabolism a driver of persistence across tissues?Mucosal immunology · 2023Review
- Tissue-specific macrophages: how they develop and choreograph tissue biology.Nature reviews. Immunology · 2023Review
- Slow integrin-dependent migration organizes networks of tissue-resident mast cells.Nature immunology · 2023Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Langerhans cells (LCs) constitute a network of immune sentinels in the skin epidermis that is seeded during embryogenesis. Whereas the development of LCs has been extensively studied, much less is known about the homeostatic renewal of adult LCs in "nonmanipulated" animals. Here, we present a new multicolor fluorescent fate mapping system and quantification approach to investigate adult LC homeostasis. This novel approach enables us to propose and provide evidence for a model in which the adult epidermal LC network is not formed by mature coequal LCs endowed with proliferative capabilities, but rather constituted by adjacent proliferative units composed of "dividing" LCs and their terminally differentiated daughter cells. Altogether, our results demonstrate the general utility of our novel fate-mapping system to follow cell population dynamics in vivo and to establish an alternative model for LC homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.