ArticlePlant physiology2013
The ureide-degrading reactions of purine ring catabolism employ three amidohydrolases and one aminohydrolase in Arabidopsis, soybean, and rice.
Article in Plant physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 76 citations in OpenAlex.
- A plastid carbohydrate carrier mediates ribose recycling from nucleotide catabolism and glucose export from starch degradation.Nature communications · 2025Article
- Allantoate Amidohydrolase OsAAH is Essential for Preharvest Sprouting Resistance in Rice.Rice (New York, N.Y.) · 2024Article
- Combined Metabolomic and Transcriptomic Analysis Reveals Allantoin Enhances Drought Tolerance in Rice.International journal of molecular sciences · 2022Article
- Enzymes and cellular interplay required for flux of fixed nitrogen to ureides in bean nodules.Nature communications · 2022Article
- Overexpression of the WAPO-A1 gene increases the number of spikelets per spike in bread wheat.Scientific reports · 2022Article
- Open Issues for Protein Function Assignment inGenes · 2021Article
- Application of Nitrate, Ammonium, or Urea Changes the Concentrations of Ureides, Urea, Amino Acids and Other Metabolites in Xylem Sap and in the Organs of Soybean Plants (International journal of molecular sciences · 2021Article
- Ureide metabolism in Arabidopsis thaliana is modulated by C:N balance.Journal of plant research · 2020Article
- Role of ureides in source-to-sink transport of photoassimilates in non-fixing soybean.Journal of experimental botany · 2020Article
- Ureide Permease 5 (AtUPS5) Connects Cell Compartments Involved in Ureide Metabolism.Plant physiology · 2020Article
- Metabolic Analyses of Nitrogen Fixation in the Soybean Microsymbiont Sinorhizobium fredii Using Constraint-Based Modeling.mSystems · 2020Article
- Nucleotide Metabolism in Plants.Plant physiology · 2020Article
- Allantoin accumulation through overexpression of ureide permease1 improves rice growth under limited nitrogen conditions.Plant biotechnology journal · 2019Article
- AMP and GMP Catabolism in Arabidopsis Converge on Xanthosine, Which Is Degraded by a Nucleoside Hydrolase Heterocomplex.The Plant cell · 2019Article
- Disruption of ureide degradation affects plant growth and development during and after transition from vegetative to reproductive stages.BMC plant biology · 2018Article
- Early Senescence in Older Leaves of Low Nitrate-GrownPlant physiology · 2018Article
- Article
- Uric acid in plants and microorganisms: Biological applications and genetics - A review.Journal of advanced research · 2017Review
- Comparative Analysis of the Combined Effects of Different Water and Phosphate Levels on Growth and Biological Nitrogen Fixation of Nine Cowpea Varieties.Frontiers in plant science · 2017Article
- Allantoin accumulation mediated by allantoinase downregulation and transport by Ureide Permease 5 confers salt stress tolerance to Arabidopsis plants.Plant molecular biology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several ureides are intermediates of purine base catabolism, releasing nitrogen from the purine nucleotides for reassimilation into amino acids. In some legumes like soybean (Glycine max), ureides are used for nodule-to-shoot translocation of fixed nitrogen. Four enzymes of Arabidopsis (Arabidopsis thaliana), (1) allantoinase, (2) allantoate amidohydrolase (AAH), (3) ureidoglycine aminohydrolase, and (4) ureidoglycolate amidohydrolase (UAH), catalyze the complete hydrolysis of the ureide allantoin in vitro. However, the metabolic route in vivo remains controversial. Here, in growth and metabolite analyses of Arabidopsis mutants, we demonstrate that these enzymes are required for allantoin degradation in vivo. Orthologous enzymes are present in soybean, encoded by one to four gene copies. All isoenzymes are active in vitro, while some may be inefficiently translated in vivo. Surprisingly, transcript and protein amounts are not significantly regulated by nitrogen fixation or leaf ureide content. A requirement for soybean AAH and UAH for ureide catabolism in leaves has been demonstrated by the use of virus-induced gene silencing. Functional AAH, ureidoglycine aminohydrolase, and UAH are also present in rice (Oryza sativa), and orthologous genes occur in all other plant genomes sequenced to date, indicating that the amidohydrolase route of ureide degradation is universal in plants, including mosses (e.g. Physcomitrella patens) and algae (e.g. Chlamydomomas reinhardtii).
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