ArticlePediatrics2013
Functional abdominal pain in childhood and long-term vulnerability to anxiety disorders.
Article in Pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04561401 (Can Brain Stimulation Enhance Outcomes Associated With Intensive Rehabilitation for Youth With Chronic Pain?), which is not on this map. Cited by 119 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Can Brain Stimulation Enhance Outcomes Associated With Intensive Rehabilitation for Youth With Chronic Pain?
Who cites it
119 citing papers in PubMed, 5 syntheses or guidelines pooled it, 269 citations in OpenAlex.
- Effect of cognitive-behavior therapy for children with functional abdominal pain: a meta-analysis.BMC gastroenterology · 2024Pooled it
- Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children and adolescents.The Cochrane database of systematic reviews · 2019Pooled it
- Dietary interventions for recurrent abdominal pain in childhood.The Cochrane database of systematic reviews · 2017Pooled it
- Psychosocial interventions for recurrent abdominal pain in childhood.The Cochrane database of systematic reviews · 2017Pooled it
- Systematic Review on Intensive Interdisciplinary Pain Treatment of Children With Chronic Pain.Pediatrics · 2015Pooled it
- The Role of Psychosocial Risk Status in Relation to Outcomes Following Cognitive Behavioral Therapy for Youth with Abdominal Pain-Related Disorders of Gut-Brain Interaction.Journal of clinical psychology in medical settings · 2026Trial
- Children with disorders of gut-brain interaction in primary care versus hospital care: A comparison of characteristics.Journal of pediatric gastroenterology and nutrition · 2025Trial
- Does Quantitative Sensory Testing Improve Prediction of Chronic Pain Trajectories? A Longitudinal Study of Youth With Functional Abdominal Pain Participating in a Randomized Controlled Trial of Cognitive Behavioral Treatment.The Clinical journal of pain · 2021Trial
- Cognitive Behavior Therapy Tailored to Anxiety Symptoms Improves Pediatric Functional Abdominal Pain Outcomes: A Randomized Clinical Trial.The Journal of pediatrics · 2021Trial
- Risk Categorization Predicts Disability in Pain-associated Functional Gastrointestinal Disorders After 6 Months.Journal of pediatric gastroenterology and nutrition · 2017Trial
- Trial
- Trial
- Iyengar yoga for adolescents and young adults with irritable bowel syndrome.Journal of pediatric gastroenterology and nutrition · 2014Trial
- Trial
- Sleep, Stress, Circadian Rhythm, and Diet in Pediatric Disorders of Gut-Brain Interaction: A Narrative Review.Nutrients · 2026Review
- Prevalence and competing risk of psychiatric comorbidities in chronic low back pain by age group.Pain reports · 2026Article
- The Etiologies and Characteristics of Chronic Abdominal Pain in Children and Adolescents in Korea.Pediatric gastroenterology, hepatology & nutrition · 2026Article
- PURSUIT Protocol: Development of a Novel Approach to Managing Youth Physical and Mental Health in Schools.Children (Basel, Switzerland) · 2026Article
- School-Related Stressors, Pain Outcome Measures and Extremely Low Health-Related Quality of Life in a Representative Sample of Hungarian Adolescents With Functional Abdominal Pain Disorders.International journal of pediatrics · 2026Article
- Time trends in cluster profiles of psychosomatic problems, self-rated poor health, and low life satisfaction from 2002 to 2022 among adolescents in five Nordic countries.BMC public health · 2025Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundCross-sectional studies link functional abdominal pain (FAP) to anxiety and depression in childhood, but no prospective study has evaluated psychiatric status in adulthood or its relation to pain persistence.
methodsPediatric patients with FAP (n = 332) and control subjects (n = 147) were tracked prospectively and evaluated for psychiatric disorders and functional gastrointestinal disorders (FGIDs) at follow-up in adolescence and young adulthood (mean age = 20.01 years). Participants were classified according to presence (FGID-POS) or absence (FGID-NEG) of FGIDs at follow-up.
resultsLifetime and current risk of anxiety disorders was higher in FAP than controls (lifetime: 51% vs 20%; current: 30% vs 12%). Controlling for gender and age, the odds ratio was 4.9 (confidence interval = 2.83-7.43) for lifetime anxiety disorder and 3.57 (confidence interval = 2.00-6.36) for current anxiety disorder at follow-up for FAP versus controls. Lifetime risk of depressive disorder was significantly higher in FAP versus controls (40% vs. 16%); current risk did not differ. In most cases, initial onset of anxiety disorders was before pediatric FAP evaluation; onset of depressive disorders was subsequent to FAP evaluation. Within the FAP group, risk of current anxiety disorders at follow-up was significantly higher for FGID-POS versus FGID-NEG (40% vs 24%), and both were higher than controls (12%); current depressive disorders did not differ across FGID-POS, FGID-NEG, and controls.
conclusionsPatients with FAP carry long-term vulnerability to anxiety that begins in childhood and persists into late adolescence and early adulthood, even if abdominal pain resolves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.