ArticleThe Journal of clinical endocrinology and metabolism2013
Isolated prolactin deficiency associated with serum autoantibodies against prolactin-secreting cells.
Article in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
- A Subset of Men With Age-Related Decline in Testosterone Have Gonadotroph Autoantibodies.The Journal of clinical endocrinology and metabolism · 2016Trial
- Breastfeeding in panhypopituitarism: a case report, review of the literature, and management checklist.International breastfeeding journal · 2026Review
- A long-lasting prolactin stimulates galactopoiesis in mice.iScience · 2025Article
- Hypopituitarism: genetic, developmental, and acquired etiologies with a focus on the emerging concept of autoimmune hypophysitis.Endocrine journal · 2025Review
- Isolated hypoprolactinemia: The rarest of the rare?Reviews in endocrine & metabolic disorders · 2024Review
- The molecular basis of hypoprolactinaemia.Reviews in endocrine & metabolic disorders · 2024Review
- Prolactin deficiency in the context of other pituitary hormone abnormalities : Special issue: hypoprolactinemia: a neglected endocrine disorder.Reviews in endocrine & metabolic disorders · 2024Review
- Cardiometabolic effects of hypoprolactinemia.Reviews in endocrine & metabolic disorders · 2024Review
- Diagnosis of hypoprolactinemia.Reviews in endocrine & metabolic disorders · 2024Review
- Evidence-based definition of hypoprolactinemia in European men aged 40-86 years: the European male ageing study.Reviews in endocrine & metabolic disorders · 2024Review
- Hypoprolactinemia. Does it matter? Redefining the hypopituitarism and return from a mumpsimus : "Absence of proof is not the proof of absence".Reviews in endocrine & metabolic disorders · 2024Review
- Neuropsychological complications of hypoprolactinemia.Reviews in endocrine & metabolic disorders · 2024Review
- Traumatic brain injury and prolactin.Reviews in endocrine & metabolic disorders · 2024Review
- Isolated anterior pituitary dysfunction in adulthood.Frontiers in endocrinology · 2023Review
- AVP deficiency (central diabetes insipidus) following immunization with anti-COVID-19 BNT162b2 Comirnaty vaccine in adolescents: A case report.Frontiers in endocrinology · 2023Article
- PRL Mutation Causing Alactogenesis: Insights Into Prolactin Structure and Function Relationships.The Journal of clinical endocrinology and metabolism · 2021Article
- Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors.Journal for immunotherapy of cancer · 2021Article
- Clinical Characteristics, Management, and Potential Biomarkers of Endocrine Dysfunction Induced by Immune Checkpoint Inhibitors.Endocrinology and metabolism (Seoul, Korea) · 2021Review
- MicroRNA-7a2 Regulates Prolactin in Developing Lactotrophs and Prolactinoma Cells.Endocrinology · 2021Article
- Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
contextIsolated prolactin (PRL) deficiency is a rare entity of unknown etiology manifesting as failure of puerperal lactogenesis.
objectiveThe aim of the study was to determine the cause of isolated PRL deficiency in an affected woman. DESIGN AND
settingWe examined genetic and autoimmune causes of isolated PRL deficiency at academic medical centers. PATIENT: The patient was a 39-year-old woman with puerperal alactogenesis after two deliveries and undetectable PRL. The other pituitary axes, serum calcium levels, and cranial magnetic resonance imaging were normal.
interventionRecombinant human PRL (r-hPRL) was administered to the patient.
main outcome measuresWe measured the sequencing of candidate genes and immunofluorescence analysis of autoantibodies directed against pituitary endocrine cells.
resultsThere were no rare sequence variants in the genes encoding for PRL, putative PRL-releasing peptide, putative PRL-releasing peptide receptor, or in other genes important for lactotroph lineage development (POU1F1, PROP1, LHX3, LHX4, HESX1, OTX2, and LSD1). The patient serum, on the contrary, contained autoantibodies that specifically recognized a subset of PRL-secreting cells but not PRL itself or any other pituitary cells or hormones. The mother was able to lactate fully after 17 days of treatment with r-hPRL 60 μg/kg every 12 hours, but alactogenesis resumed after treatment was completed.
conclusionsThese studies report a new autoimmune etiology for women with isolated PRL deficiency and puerperal alactogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.