Evidence map›Paper›PMID 23940096›Full record

ReviewNMR in biomedicine2014

The role of metabolic imaging in radiation therapy of prostate cancer.

V Y Zhang, A Westphalen, L Delos Santos, Z L Tabatabai, K Shinohara, D B Vigneron, J Kurhanewicz

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in NMR in biomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Simultaneous Metabolic and Perfusion Imaging Using HyperpolarizedInternational journal of radiation oncology, biology, physics · 2020
    Article
  6. Article
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

V Y ZhangDepartment of Radiology and Biomedical Imaging, University of California San Francisco (UCSF), CA, USA.
A Westphalen
L Delos Santos
Z L Tabatabai
K Shinohara
D B Vigneron
J Kurhanewicz
University of California, San Francisco · USUniversity of California System · US

Funding

METABOLIC IMAGING OF THE PROSTATE USING 3D MRSIR01CA059897 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VIGNERON, DANIEL B · 1993 to 2011
$4.8M
Morphologic, Metabolic and Functional Prostate ImagingR01CA111291 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VIGNERON, DANIEL B · 2006 to 2010
$4.2M
Translation and Evaluation of a Multiparametric Prostate Cancer 3T ExamR01CA137207 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HURD, RALPH EUGENE, KURHANEWICZ, JOHN · 2010 to 2014
$2.6M
MONITORING RADIATION THERAPY OF PROSTATE CANCER BY MRSIR01CA079980 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN · 1999 to 2008
$2.6M
NCI NIH HHS NIH R01-CA137207NCI NIH HHS R01 CA059897NCI NIH HHS R01-CA059897NCI NIH HHS R01 CA079980NCI NIH HHS R01 CA111291NCI NIH HHS R01-CA111291NCI NIH HHS R01 CA137207
6 · The paper itself

Abstract

The goal of this study was to correlate prostatic metabolite concentrations from snap-frozen patient biopsies of recurrent cancer after failed radiation therapy with histopathological findings, including Ki-67 immunohistochemistry and pathologic grade, in order to identify quantitative metabolic biomarkers that predict for residual aggressive versus indolent cancer. A total of 124 snap-frozen transrectal ultrasound (TRUS)-guided biopsies were acquired from 47 men with untreated prostate cancer and from 39 men with a rising prostate-specific antigen and recurrent prostate cancer following radiation therapy. Biopsy tissues with Ki-67 labeling index ≤ 5% were classified as indolent cancer, while biopsy tissues with Ki-67 labeling index > 5% were classified as aggressive cancer. The majority (15 out of 17) of cancers classified as aggressive had a primary Gleason 4 pattern (Gleason score ≥ 4 + 3). The concentrations of choline-containing phospholipid metabolites (PC, GPC, and free Cho) and lactate were significantly elevated in recurrent cancer relative to surrounding benign tissues. There was also a significant increase in [PC] and reduction in [GPC] between untreated and irradiated prostate cancer biopsies. The concentration of the choline-containing phospholipid metabolites was significantly higher in recurrent aggressive (≈ twofold) than in recurrent indolent cancer biopsies, and the receiver operating characteristic (ROC) curve analysis of total choline to creatine ratio (tCho/Cr) demonstrated an accuracy of 95% (confidence interval = 0.88-1.00) for predicting aggressive recurrent disease. The tCho/Cr was significantly higher for identifying recurrent aggressive versus indolent cancer (tCho/Cr = 2.4 ± 0.4 versus 1.5 ± 0.2), suggesting that use of a higher threshold tCho/Cr ratio in future in vivo (1)H MRSI studies could improve the selection and therapeutic planning for patients who would benefit most from salvage focal therapy after failed radiation therapy.

Indexed as

AgedBiopsyCreatineDiagnostic ImagingHumansKi-67 AntigenMaleMetabolomicsPhosphorylcholineProstateProstatic NeoplasmsRadiographyCreatineKi-67 AntigenPhosphorylcholineGleason scoreHR-MASKi-67MR spectroscopypathologic gradephospholipid metabolismprostate cancerradiation therapy

Identifiers

PMID23940096
PMCPMC3864570
OpenAlexW1551372829

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.