ArticleThe Journal of biological chemistry2013
The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase Coq7 in yeast.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Type 2C protein phosphatases (PP2Cs) regulate cell proliferation in the yeast Saccharomyces cerevisiae.Molecular biology reports · 2026Article
- Recessive PPTC7 deficiency triggers excessive mitophagy to cause a severe inborn error of metabolism with hypomyelinating leukodystrophy.Research square · 2026Article
- Dual-localized PPTC7 limits mitophagy through proximal and dynamic interactions with BNIP3 and NIX.Life science alliance · 2024Article
- PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy.Nature communications · 2023Article
- Pptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy.bioRxiv : the preprint server for biology · 2023Article
- Recent advances in the metabolic pathways and microbial production of coenzyme Q.World journal of microbiology & biotechnology · 2022Review
- A dedicated flavin-dependent monooxygenase catalyzes the hydroxylation of demethoxyubiquinone into ubiquinone (coenzyme Q) in Arabidopsis.The Journal of biological chemistry · 2021Article
- Ser/Thr protein phosphatases in fungi: structure, regulation and function.Microbial cell (Graz, Austria) · 2019Review
- Protein phosphatases of Saccharomyces cerevisiae.Current genetics · 2019Review
- Coenzyme QEssays in biochemistry · 2018Review
- Coenzyme QFrontiers in physiology · 2018Review
- Ethanol's Effect onFrontiers in genetics · 2018Article
- Chromatin-remodeling SWI/SNF complex regulates coenzyme QThe Journal of biological chemistry · 2017Article
- Biochemical Assessment of Coenzyme QJournal of clinical medicine · 2017Review
- Balanced CoQMicrobial cell (Graz, Austria) · 2017Article
- Ptc7p Dephosphorylates Select Mitochondrial Proteins to Enhance Metabolic Function.Cell reports · 2017Article
- RNA-binding proteins regulate cell respiration and coenzyme Q biosynthesis by post-transcriptional regulation of COQ7.RNA biology · 2016Article
- CLD1 Reverses the Ubiquinone Insufficiency of Mutant cat5/coq7 in a Saccharomyces cerevisiae Model System.PloS one · 2016Article
- The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene.EMBO molecular medicine · 2015Article
- Lipid metabolism in mitochondrial membranes.Journal of inherited metabolic disease · 2015Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study of the components of mitochondrial metabolism has potential benefits for health span and lifespan because the maintenance of efficient mitochondrial function and antioxidant capacity is associated with improved health and survival. In yeast, mitochondrial function requires the tight control of several metabolic processes such as coenzyme Q biosynthesis, assuring an appropriate energy supply and antioxidant functions. Many mitochondrial processes are regulated by phosphorylation cycles mediated by protein kinases and phosphatases. In this study, we determined that the mitochondrial phosphatase Ptc7p, a Ser/Thr phosphatase, was required to regulate coenzyme Q6 biosynthesis, which in turn activated aerobic metabolism and enhanced oxidative stress resistance. We showed that Ptc7p phosphatase specifically activated coenzyme Q6 biosynthesis through the dephosphorylation of the demethoxy-Q6 hydroxylase Coq7p. The current findings revealed that Ptc7p is a regulator of mitochondrial metabolism that is essential to maintain proper function of the mitochondria by regulating energy metabolism and oxidative stress resistance.
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