ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2013
Histological confirmation and biological significance of cartilage canals demonstrated using high field MRI in swine at predilection sites of osteochondrosis.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Ossification variants of the distal femoral condyle: longitudinal 3 T MRI evidence of progression to juvenile osteochondritis dissecans in asymptomatic siblings of patients with JOCD.Skeletal radiology · 2026Article
- Magnetic resonance-enhanced high-resolution three-dimensional water-selective cartilage sequence visualization of hip vessels in children.International orthopaedics · 2024Article
- Ultra-high-field MRI of postmortem human fetal wrist joints: initial experience.European radiology experimental · 2023Article
- A method for labelling lesions for machine learning and some new observations on osteochondrosis in computed tomographic scans of four pig joints.BMC veterinary research · 2022Article
- Vascularity of the early post-natal human distal femoral chondroepiphysis: Quantitative MRI analysis.Journal of children's orthopaedics · 2022Article
- Epiphyseal cartilage canal architecture and extracellular matrix remodeling in mucopolysaccharidosis VII dogs at the onset of postnatal growth.Connective tissue research · 2021Article
- Quantitative susceptibility mapping detects neovascularization of the epiphyseal cartilage after ischemic injury in a piglet model of legg-calvé-perthes disease.Journal of magnetic resonance imaging : JMRI · 2019Article
- Vessel architecture in human knee cartilage in children: an in vivo susceptibility-weighted imaging study at 7 T.European radiology · 2018Article
- Non-linear optical microscopy of cartilage canals in the distal femur of young pigs may reveal the cause of articular osteochondrosis.BMC veterinary research · 2017Article
- Quantitative susceptibility mapping detects abnormalities in cartilage canals in a goat model of preclinical osteochondritis dissecans.Magnetic resonance in medicine · 2017Article
- Novel Application of Magnetic Resonance Imaging Demonstrates Characteristic Differences in Vasculature at Predilection Sites of Osteochondritis Dissecans.The American journal of sports medicine · 2015Article
- Pre-clinical characterization of tissue engineering constructs for bone and cartilage regeneration.Annals of biomedical engineering · 2015Review
- Development of a Large Animal Model of Osteochondritis Dissecans of the Knee: A Pilot Study.Orthopaedic journal of sports medicine · 2015Article
- Surgical induction, histological evaluation, and MRI identification of cartilage necrosis in the distal femur in goats to model early lesions of osteochondrosis.Osteoarthritis and cartilage · 2015Article
- Improved Visualization of Cartilage Canals Using Quantitative Susceptibility Mapping.PloS one · 2015Article
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7 authors at 2 institutions in 1 country.
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Abstract
Cartilage canal vessels in epiphyseal cartilage have a pivotal role in the pathogenesis of osteochondrosis/osteochondritis dissecans. The present study aimed to validate high field magnetic resonance imaging (MRI) methods to visualize these vessels in young pigs. Osteochondral samples from the distal femur and distal humerus (predilection sites of osteochondrosis) of piglets were imaged post-mortem: (1) using susceptibility-weighted imaging (SWI) in an MRI scanner, followed by histological evaluation; and (2) after barium perfusion using µCT, followed by clearing techniques. In addition, both stifle joints of a 25-day-old piglet were imaged in vivo using SWI and gadolinium enhanced T1-weighted MRI, after which distal femoral samples were harvested and evaluated using µCT and histology. Histological sections were compared to corresponding MRI slices, and three-dimensional visualizations of vessels identified using MRI were compared to those obtained using µCT and to the cleared specimens. Vessels contained in cartilage canals were identified using MRI, both ex vivo and in vivo; their locations matched those observed in the histological sections, µCT images, and cleared specimens of barium-perfused tissues. The ability to visualize cartilage canal blood vessels by MRI, without using a contrast agent, will allow future longitudinal studies to evaluate their role in developmental orthopedic disease.
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