ArticleEuropean journal of immunology2013
Interference with Ca(2+) release activated Ca(2+) (CRAC) channel function delays T-cell arrest in vivo.
Article in European journal of immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Synthetic Biology Meets CaCells · 2024Review
- The role of ion channels in T cell function and disease.Frontiers in immunology · 2023Review
- How the Potassium Channel Response of T Lymphocytes to the Tumor Microenvironment Shapes Antitumor Immunity.Cancers · 2022Review
- Autoimmunity in motion: Mechanisms of immune regulation and destruction revealed by in vivo imaging.Immunological reviews · 2022Review
- Memory CD8Science advances · 2021Article
- Strength and Numbers: The Role of Affinity and Avidity in the 'Quality' of T Cell Tolerance.Cells · 2021Review
- Overview of CaExploration of targeted anti-tumor therapy · 2021Review
- CRAC Channels and Calcium Signaling in T Cell-Mediated Immunity.Trends in immunology · 2020Review
- Gut Bacterial Metabolite Urolithin A (UA) Mitigates CaFrontiers in immunology · 2019Article
- Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division.The Journal of experimental medicine · 2018Article
- Intermittent CaeLife · 2017Article
- Epigallocatechin-3-gallate (EGCG) up-regulates miR-15b expression thus attenuating store operated calcium entry (SOCE) into murine CD4Oncotarget · 2017Article
- Imaging of anticancer drug action in single cells.Nature reviews. Cancer · 2017Review
- Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The functional contribution of calcium ion flux heterogeneity in T cells.Immunology and cell biology · 2015Review
- STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection.The Journal of clinical investigation · 2015Article
- Ion channels in innate and adaptive immunity.Annual review of immunology · 2015Review
- TRP channels and STIM/ORAI proteins: sensors and effectors of cancer and stroma cell migration.British journal of pharmacology · 2014Review
- "Cell biology meets physiology: functional organization of vertebrate plasma membranes"--the immunological synapse.Current topics in membranes · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Entry of lymphocytes into secondary lymphoid organs (SLOs) involves intravascular arrest and intracellular calcium ion ([Ca(2+)]i) elevation. TCR activation triggers increased [Ca(2+)]i and can arrest T-cell motility in vitro. However, the requirement for [Ca(2+)]i elevation in arresting T cells in vivo has not been tested. Here, we have manipulated the Ca(2+) release-activated Ca(2+) (CRAC) channel pathway required for [Ca(2+)]i elevation in T cells through genetic deletion of stromal interaction molecule (STIM) 1 or by expression of a dominant-negative ORAI1 channel subunit (ORAI1-DN). Interestingly, the absence of CRAC did not interfere with homing of naïve CD4(+) T cells to SLOs and only moderately reduced crawling speeds in vivo. T cells expressing ORAI1-DN lacked TCR activation induced [Ca(2+)]i elevation, yet arrested motility similar to control T cells in vitro. In contrast, antigen-specific ORAI1-DN T cells had a twofold delayed onset of arrest following injection of OVA peptide in vivo. CRAC channel function is not required for homing to SLOs, but enhances spatiotemporal coordination of TCR signaling and motility arrest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.