ArticleAntimicrobial agents and chemotherapy2013
Nontoxigenic Clostridium difficile protects hamsters against challenge with historic and epidemic strains of toxigenic BI/NAP1/027 C. difficile.
Article in Antimicrobial agents and chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 72 citations in OpenAlex.
- Article
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- Protection againstbioRxiv : the preprint server for biology · 2024Article
- A local-scale One Health genomic surveillance ofMicrobial genomics · 2023Article
- Non-ToxigenicAntibiotics (Basel, Switzerland) · 2023Article
- Food for thought-The link between Clostridioides difficile metabolism and pathogenesis.PLoS pathogens · 2023Review
- The Mechanism of Important Components in Canine Fecal Microbiota Transplantation.Veterinary sciences · 2022Review
- Towards Development of a Non-ToxigenicPharmaceutics · 2022Article
- Genomic and Phenotypic Characterization of the Nontoxigenic Clostridioides difficile Strain CCUG37785 and Demonstration of Its Therapeutic Potential for the Prevention of C. difficile Infection.Microbiology spectrum · 2022Article
- Disordered Intestinal Microbial Communities DuringFrontiers in cellular and infection microbiology · 2022Article
- Article
- Host Immune Responses toFrontiers in microbiology · 2021Review
- Characterization of Non-ToxigenicJournal of clinical medicine · 2020Article
- Detection and elimination of a novel non-toxigenicGut microbes · 2020Article
- Diarrhoeal events can trigger long-term Clostridium difficile colonization with recurrent blooms.Nature microbiology · 2020Article
- Epidemiology and virulence-associated genes ofAccess microbiology · 2020Article
- Developing Gut Microbiota Exerts Colonisation Resistance toMicroorganisms · 2019Article
- RecurrentGut and liver · 2019Review
- Phenotypic Characterization of Non-toxigenicFrontiers in microbiology · 2019Article
- Evaluation of growth and sporulation of a non-toxigenic strain of Clostridioides difficile (Z31) and its shelf viability.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nontoxigenic Clostridium difficile (NTCD) has been shown to prevent fatal C. difficile infection in the hamster model when hamsters are challenged with standard toxigenic C. difficile strains. The purpose of this study was to determine if NTCD can prevent C. difficile infection in the hamster model when hamsters are challenged with restriction endonuclease analysis group BI C. difficile strains. Groups of 10 hamsters were given oral clindamycin, followed on day 2 by 10(6) CFU of spores of NTCD strain M3 or T7, and were challenged on day 5 with 100 CFU of spores of BI1 or BI6. To conserve animals, results for control hamsters challenged with BI1 or BI6 from the present study and controls from previous identical experiments were combined for statistical comparisons. NTCD strains M3 and T7 achieved 100% colonization and were 100% protective against challenge with BI1 (P ≤ 0.001). M3 colonized 9/10 hamsters and protected against BI6 challenge in the colonized hamsters (P = 0.0003). T7 colonized 10/10 hamsters, but following BI6 challenge, cocolonization occurred in 5 hamsters, 4 of which died, for protection of 6/10 animals (P = 0.02). NTCD colonization provides protection against challenge with toxigenic BI group strains. M3 is more effective than T7 in preventing C. difficile infection caused by the BI6 epidemic strain. Prevention of C. difficile infection caused by the epidemic BI6 strain may be more challenging than that of infections caused by historic BI1 and non-BI C. difficile strains.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.