ArticleLab on a chip2013
Smart-phone based computational microscopy using multi-frame contact imaging on a fiber-optic array.
Article in Lab on a chip, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 112 citations in OpenAlex.
- Advances in Portable Optical Microscopy Using Cloud Technologies and Artificial Intelligence for Medical Applications.Sensors (Basel, Switzerland) · 2024Review
- Microfluidic Devices for HIV Diagnosis and Monitoring at Point-of-Care (POC) Settings.Biosensors · 2022Review
- Microscopic Imaging Methods for Organ-on-a-Chip Platforms.Micromachines · 2022Review
- Multi-frequency impedance sensing for detection and sizing of DNA fragments.Scientific reports · 2021Article
- Rapid Yeast Cell Viability Analysis by Using a Portable Microscope Based on the Fiber Optic Array and Simple Image Processing.Sensors (Basel, Switzerland) · 2020Article
- Enhancing the Usability of an Optical Reader System to Support Point-of-Care Rapid Diagnostic Testing: An Iterative Design Approach.JMIR human factors · 2017Article
- Recent Progress in Optical Biosensors Based on Smartphone Platforms.Sensors (Basel, Switzerland) · 2017Review
- Smartphone-Based Endoscope System for Advanced Point-of-Care Diagnostics: Feasibility Study.JMIR mHealth and uHealth · 2017Article
- Compact, cost-effective and field-portable microscope prototype based on MISHELF microscopy.Scientific reports · 2017Article
- Multimodal Imaging and Lighting Bias Correction for Improved μPAD-based Water Quality Monitoring via Smartphones.Scientific reports · 2016Article
- Sickle cell detection using a smartphone.Scientific reports · 2015Article
- Medically relevant assays with a simple smartphone and tablet based fluorescence detection system.Sensors (Basel, Switzerland) · 2015Article
- Image decoding of photonic crystal beads array in the microfluidic chip for multiplex assays.Scientific reports · 2014Article
- Various on-chip sensors with microfluidics for biological applications.Sensors (Basel, Switzerland) · 2014Review
- Smartphone technology can be transformative to the deployment of lab-on-chip diagnostics.Lab on a chip · 2014Article
- Biomedical imaging and sensing using flatbed scanners.Lab on a chip · 2014Review
- Mobile phones democratize and cultivate next-generation imaging, diagnostics and measurement tools.Lab on a chip · 2014Article
- A smartphone-based chip-scale microscope using ambient illumination.Lab on a chip · 2014Article
- High-throughput monitoring of major cell functions by means of lensfree video microscopy.Scientific reports · 2014Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
We demonstrate a cellphone based contact microscopy platform, termed Contact Scope, which can image highly dense or connected samples in transmission mode. Weighing approximately 76 grams, this portable and compact microscope is installed on the existing camera unit of a cellphone using an opto-mechanical add-on, where planar samples of interest are placed in contact with the top facet of a tapered fiber-optic array. This glass-based tapered fiber array has ~9 fold higher density of fiber optic cables on its top facet compared to the bottom one and is illuminated by an incoherent light source, e.g., a simple light-emitting-diode (LED). The transmitted light pattern through the object is then sampled by this array of fiber optic cables, delivering a transmission image of the sample onto the other side of the taper, with ~3× magnification in each direction. This magnified image of the object, located at the bottom facet of the fiber array, is then projected onto the CMOS image sensor of the cellphone using two lenses. While keeping the sample and the cellphone camera at a fixed position, the fiber-optic array is then manually rotated with discrete angular increments of e.g., 1-2 degrees. At each angular position of the fiber-optic array, contact images are captured using the cellphone camera, creating a sequence of transmission images for the same sample. These multi-frame images are digitally fused together based on a shift-and-add algorithm through a custom-developed Android application running on the smart-phone, providing the final microscopic image of the sample, visualized through the screen of the phone. This final computation step improves the resolution and also removes spatial artefacts that arise due to non-uniform sampling of the transmission intensity at the fiber optic array surface. We validated the performance of this cellphone based Contact Scope by imaging resolution test charts and blood smears.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.