Trial reportDiabetes2013
Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes.
Trial report in Diabetes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Neuroinflammation Markers in Tear Fluid of Mild Alzheimer's Disease.Journal of molecular neuroscience : MN · 2025Article
- Whole genome sequencing of mouse lines divergently selected for fatness (FLI) and leanness (FHI) revealed several genetic variants as candidates for novel obesity genes.Genes & genomics · 2024Article
- Differential methylation pattern in pubertal girls associated with biochemical premature adrenarche.Epigenetics · 2023Article
- Further evidence supporting a potential role for ADH1B in obesity.Scientific reports · 2021Article
- CPPED1-targeting microRNA-371a-5p expression in human placenta associates with spontaneous delivery.PloS one · 2020Article
- Liver Transcriptomic Reveals Novel Pathways of Empagliflozin Associated With Type 2 Diabetic Rats.Frontiers in endocrinology · 2020Article
- Comparative Transcriptome and Proteome Analysis of Heat Acclimation in Predatory MiteFrontiers in physiology · 2020Article
- Proteome characteristics of liver tissue from patients with parenteral nutrition-associated liver disease.Nutrition & metabolism · 2020Article
- Article
- Article
- Additional common variants associated with type 2 diabetes and coronary artery disease detected using a pleiotropic cFDR method.Journal of diabetes and its complications · 2018Article
- Expression of CPPED1 in human trophoblasts is associated with timing of term birth.Journal of cellular and molecular medicine · 2018Article
- A Transcriptomic Comparison of Two Bambara Groundnut Landraces under Dehydration Stress.Genes · 2017Article
- Identification of miRNA-mRNA crosstalk in CD4Journal of translational medicine · 2017Article
- The Mechanisms Underlying the Hypolipidaemic Effects of Grifola frondosa in the Liver of Rats.Frontiers in microbiology · 2016Article
- Identification of putative SNPs in progressive retinal atrophy affected Canis lupus familiaris using exome sequencing.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously demonstrated that the expression of calcineurin-like phosphoesterase domain containing 1 (CPPED1) decreases in adipose tissue (AT) after weight reduction. However, the function of CPPED1 in AT is unknown. Therefore, we investigated whether the change in CPPED1 expression is connected to changes in adipocyte glucose metabolism. First, we confirmed that the expression of CPPED1 decreased after weight loss in subcutaneous AT. Second, the expression of CPPED1 did not change during adipocyte differentiation. Third, CPPED1 knockdown with small interfering RNA increased expression of genes involved in glucose metabolism (adiponectin, adiponectin receptor 1, and GLUT4) and improved insulin-stimulated glucose uptake. To conclude, CPPED1 is a novel molecule involved in AT biology, and CPPED1 is involved in glucose uptake in adipocytes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.