Evidence map›Paper›PMID 23939026›Full record

ArticleThe Analyst2013

Generation of a chemical gradient across an array of 256 cell cultures in a single chip.

Himali Somaweera, Akif Ibragimov, Dimitri Pappas

Abstract read
In one paragraph

Article in The Analyst, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Himali SomaweeraDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA. d.pappas@ttu.edu.
Akif Ibragimov
Dimitri Pappas

Funding

Rapid Single Molecule Detection System for Intracellular Protease ActivityR21RR025782 · NCRR · TEXAS TECH UNIVERSITY · PI PAPPAS, DIMITRI · 2010 to 2011
$346k
Rapid Single Molecule Detection System for Intracellular Protease ActivityR21GM103550 · NIGMS · TEXAS TECH UNIVERSITY · PI PAPPAS, DIMITRI · 2012 to 2012
$172k
NCRR NIH HHS R21 RR025782NCRR NIH HHS RR025782NIGMS NIH HHS GM103550NIGMS NIH HHS R21 GM103550
6 · The paper itself

Abstract

A microfluidic diffusion diluter to create stable chemical gradients across an array of cell cultures was demonstrated. The device enabled concentration based studies to be conducted at 256 different concentrations across individual, low shear cell cultures. A gradient of staurosporine on cells stained with Mitotracker Deep Red (MTDR) showed a concentration-based effect on cell apoptosis across the cell culture array.

Indexed as

Cell Culture TechniquesCell SurvivalHumansMicroarray AnalysisMicrofluidic Analytical Techniques

Identifiers

PMID23939026
PMCPMC3857027

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.