ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2013
Identification of an ancient endogenous retrovirus, predating the divergence of the placental mammals.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
- Mutation Rate Variation and Other Challenges in 2-LTR Dating of Primate Endogenous Retrovirus Integrations.Journal of molecular evolution · 2025Review
- Endogenous Caulimovirids: Fossils, Zombies, and Living in Plant Genomes.Biomolecules · 2023Review
- Review
- Increased levels of endogenous retroviruses trigger fibroinflammation and play a role in kidney disease development.Nature communications · 2023Article
- Evolutionary Analysis of Placental Orthologues Reveals Two Ancient DNA Virus Integrations.Journal of virology · 2022Article
- Article
- Mapping the evolution of bornaviruses across geological timescales.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Phylogenomics of the Maverick Virus-Like Mobile Genetic Elements of Vertebrates.Molecular biology and evolution · 2021Article
- Retroviral integrations contribute to elevated host cancer rates during germline invasion.Nature communications · 2021Article
- Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing.Journal of visualized experiments : JoVE · 2020Article
- Baby Genomics: Tracing the Evolutionary Changes That Gave Rise to Placentation.Genome biology and evolution · 2020Article
- Retroviruses of the Human Virobiota: The Recycling of Viral Genes and the Resulting Advantages for Human Hosts During Evolution.Frontiers in microbiology · 2020Review
- Article
- Origins and evolutionary consequences of ancient endogenous retroviruses.Nature reviews. Microbiology · 2019Review
- Article
- Structure, clustering and functional insights of repeats configurations in the upstream promoter region of the human coding genes.BMC genomics · 2018Article
- Distribution, Diversity, and Evolution of Endogenous Retroviruses in Perissodactyl Genomes.Journal of virology · 2018Article
- Nomenclature for endogenous retrovirus (ERV) loci.Retrovirology · 2018Review
- Reconstruction of a replication-competent ancestral murine endogenous retrovirus-L.Retrovirology · 2018Article
- The Diversity, Structure, and Function of Heritable Adaptive Immunity Sequences in the Aedes aegypti Genome.Current biology : CB · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The evolutionary arms race between mammals and retroviruses has long been recognized as one of the oldest host-parasite interactions. Rapid evolution rates in exogenous retroviruses have often made accurate viral age estimations highly problematic. Endogenous retroviruses (ERVs), however, integrate into the germline of their hosts, and are subjected to their evolutionary rates. This study describes, for the first time, a retroviral orthologue predating the divergence of placental mammals, giving it a minimum age of 104-110 Myr. Simultaneously, other orthologous selfish genetic elements (SGEs), inserted into the ERV sequence, provide evidence for the oldest individual mammalian-wide interspersed repeat and medium-reiteration frequency interspersed repeat mammalian repeats, with the same minimum age. The combined use of shared SGEs and reconstruction of viral orthologies defines new limits and increases maximum 'lookback' times, with subsequent implications for the field of paleovirology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.