ArticleJournal of Parkinson's disease2013
Dopamine agonists rather than deep brain stimulation cause reflection impulsivity in Parkinson's disease.
Article in Journal of Parkinson's disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 3 citations in OpenAlex.
- Decisional impulsivity and the associative-limbic subthalamic nucleus in obsessive-compulsive disorder: stimulation and connectivity.Brain : a journal of neurology · 2017Trial
- Waiting Impulsivity: The Influence of Acute Methylphenidate and Feedback.The international journal of neuropsychopharmacology · 2015Trial
- Cognitive structure and progression in Parkinson's disease: insights from a tablet-based assessment.Scientific reports · 2026Article
- Neuropsychological aspects of impulse control disorders in Parkinson's disease.Frontiers in aging neuroscience · 2026Review
- Active information sampling in health and disease.Neuroscience and biobehavioral reviews · 2025Review
- Impulse Control Disorders in Parkinson's Disease: An Overview of Risk Factors, Pathogenesis and Pharmacological Management.CNS drugs · 2024Review
- In Parkinson's disease dopaminergic medication and deep brain stimulation of the subthalamic nucleus increase motor, but not reflection and cognitive impulsivity.Frontiers in neuroscience · 2024Article
- Neural correlates of overvaluation and the effort to save possessions in a novel decision task: An exploratory fMRI study.Frontiers in psychology · 2023Article
- Dynamic control of decision and movement speed in the human basal ganglia.Nature communications · 2022Article
- A literature review of dopamine in binge eating.Journal of eating disorders · 2022Review
- Subthalamic nucleus deep brain stimulation and impulsivity in Parkinson's disease: a descriptive review.Acta neurologica Belgica · 2021Review
- Decision making and framing effects in multiple sclerosis.European journal of neurology · 2021Article
- Birds of a Feather Flock Together: Disadvantageous Decision Making in Augmented Restless Legs Syndrome Patients with and without Impulse Control Disorders.Brain sciences · 2021Article
- Review
- Time will tell: Decision making in premanifest and manifest Huntington's disease.Brain and behavior · 2020Article
- The effect on deep brain stimulation of subthalamic nucleus and dopaminergic treatment in Parkinson disease.Medicine · 2020Article
- Dopamine manipulations drive changes in information sampling in healthy volunteers.Journal of psychopharmacology (Oxford, England) · 2019Article
- Moderation of the relationship between Toxoplasma gondii seropositivity and trait impulsivity in younger men by the phenylalanine-tyrosine ratio.Psychiatry research · 2018Article
- Reflection impulsivity perceptual decision-making in patients with restless legs syndrome.Annals of clinical and translational neurology · 2018Article
- Impulsivity in Parkinson's Disease Is Associated With Alterations in Affective and Sensorimotor Striatal Networks.Frontiers in neurology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundDopamine agonist therapy is the main risk factor for impulse control disorders in Parkinson's disease (PD). However, it is unclear whether bilateral deep brain stimulation of the subthalamic nucleus also causes impairment in decision making.
objectivesTo assess the role of dopamine agonist therapy and deep brain stimulation on reflection impulsivity in non-demented patients with PD.
methodsWe recruited 61 PD patients, 20 treated with L-dopa in combination with a dopamine agonist, 14 taking L-dopa monotherapy, a further 16 PD patients with bilateral subthalamic nucleus deep brain stimulation treated with L-dopa in combination with a dopamine agonist, and 11 PD patients with bilateral subthalamic nucleus deep brain stimulation taking L-dopa but not a dopamine agonist. Results were compared with 18 healthy controls. Patients who had evidence of impulsive compulsive behaviour were excluded. Reflection impulsivity was assessed with the beads task, which is a validated information sampling task.
resultsAll patients treated with a dopamine agonist gathered significantly less information and made more irrational decisions than all other groups regardless of whether they had surgical treatment.
conclusionsOur results imply that dopamine agonist therapy but not deep brain stimulation leads to "reflection impulsivity" in PD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.