Evidence map›Paper›PMID 23938199›Full record

ReviewActa biomaterialia2014

Tropoelastin: a versatile, bioactive assembly module.

Steven G Wise, Giselle C Yeo, Matti A Hiob, Jelena Rnjak-Kovacina, David L Kaplan, Martin K C Ng, Anthony S Weiss

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta biomaterialia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 134 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Steven G WiseThe Heart Research Institute, Sydney, NSW 2042, Australia; Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia; School of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia.
Giselle C YeoSchool of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia.
Matti A HiobSchool of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia; The Heart Research Institute, Sydney, NSW 2042, Australia.
Jelena Rnjak-KovacinaDepartment of Biomedical Engineering, School of Engineering, Tufts University, Medford, MA 02155, USA.
David L KaplanDepartment of Biomedical Engineering, School of Engineering, Tufts University, Medford, MA 02155, USA.
Martin K C NgThe Heart Research Institute, Sydney, NSW 2042, Australia; Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia.
Anthony S WeissSchool of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia; Bosch Institute, University of Sydney, Sydney, NSW 2006, Australia; Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia. Electronic address: tony.weiss@sydney.edu.au.
University of Sydney · AUTufts University · USRoyal Prince Alfred Hospital · AUThe Heart Research Institute · AU

Funding

Multifunctional Tropoelastin-Silk Biomaterial SystemsR01EB014283 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2012 to 2015
$1.2M
NIBIB NIH HHS EB014283NIBIB NIH HHS R01 EB014283
6 · The paper itself

Abstract

Elastin provides structural integrity, biological cues and persistent elasticity to a range of important tissues, including the vasculature and lungs. Its critical importance to normal physiology makes it a desirable component of biomaterials that seek to repair or replace these tissues. The recent availability of large quantities of the highly purified elastin monomer, tropoelastin, has allowed for a thorough characterization of the mechanical and biological mechanisms underpinning the benefits of mature elastin. While tropoelastin is a flexible molecule, a combination of optical and structural analyses has defined key regions of the molecule that directly contribute to the elastomeric properties and control the cell interactions of the protein. Insights into the structure and behavior of tropoelastin have translated into increasingly sophisticated elastin-like biomaterials, evolving from classically manufactured hydrogels and fibers to new forms, stabilized in the absence of incorporated cross-linkers. Tropoelastin is also compatible with synthetic and natural co-polymers, expanding the applications of its potential use beyond traditional elastin-rich tissues and facilitating finer control of biomaterial properties and the design of next-generation tailored bioactive materials.

Indexed as

AnimalsBiocompatible MaterialsHumansPolymersTropoelastinBiocompatible MaterialsPolymersTropoelastinBiomaterialsElasticityElastinStructureTropoelastin

Identifiers

PMID23938199
PMCPMC3879170
OpenAlexW2036735375

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.