ArticleBiomaterials2013
3D graphene oxide-encapsulated gold nanoparticles to detect neural stem cell differentiation.
Article in Biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Molecular Stress Response of Mitochondria during Electrostimulation Evoking Stem Cell Differentiation Revealed by Fluorescence Imaging Combined with SERS Spectra.ACS measurement science au · 2025Article
- Recent advances in two-dimensional materials for the diagnosis and treatment of neurodegenerative diseases.Discover nano · 2024Review
- Paper/GO/e-Au flexible SERS sensors forNanoscale advances · 2024Article
- Nano biomaterials based strategies for enhanced brain targeting in the treatment of neurodegenerative diseases: an up-to-date perspective.Journal of nanobiotechnology · 2023Review
- Nanocomposite Hydrogels as Functional Extracellular Matrices.Gels (Basel, Switzerland) · 2023Review
- The mechanical, optical, and thermal properties of graphene influencing its pre-clinical use in treating neurological diseases.Frontiers in neuroscience · 2023Review
- Stem cells as potential therapeutics for hearing loss.Frontiers in neuroscience · 2023Review
- Inorganic Nanoparticles-Based Systems in Biomedical Applications of Stem Cells: Opportunities and Challenges.International journal of nanomedicine · 2023Review
- TiAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Graphene-Based Materials for Efficient Neurogenesis.Advances in experimental medicine and biology · 2022Article
- Multimodal Label-Free Monitoring of Adipogenic Stem Cell Differentiation Using Endogenous Optical Biomarkers.Advanced functional materials · 2021Article
- Regulation of Stem Cell Differentiation by Inorganic Nanomaterials: Recent Advances in Regenerative Medicine.Frontiers in bioengineering and biotechnology · 2021Review
- Article
- Metallic Nanoparticle-Based Optical Cell Chip for Nondestructive Monitoring of Intra/Extracellular Signals.Pharmaceutics · 2020Review
- Regulation of Neural Stem Cell Proliferation and Differentiation by Graphene-Based Biomaterials.Neural plasticity · 2019Review
- Current and novel polymeric biomaterials for neural tissue engineering.Journal of biomedical science · 2018Review
- Generation of uniform-sized multicellular tumor spheroids using hydrogel microwells for advanced drug screening.Scientific reports · 2018Article
- The Impact of Metallic Nanoparticles on Stem Cell Proliferation and Differentiation.Nanomaterials (Basel, Switzerland) · 2018Review
- Nanobiosensing Platforms for Real-Time and Non-Invasive Monitoring of Stem Cell Pluripotency and Differentiation.Sensors (Basel, Switzerland) · 2018Review
- Magnetic Force-Driven Graphene Patterns to Direct Synaptogenesis of Human Neuronal Cells.Materials (Basel, Switzerland) · 2017Article
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Abstract
Monitoring of stem cell differentiation and pluripotency is an important step for the practical use of stem cells in the field of regenerative medicine. Hence, a new non-destructive detection tool capable of in situ monitoring of stem cell differentiation is highly needed. In this study, we report a 3D graphene oxide-encapsulated gold nanoparticle that is very effective for the detection of the differentiation potential of neural stem cells (NSCs) based on surface-enhanced Raman spectroscopy (SERS). A new material, 3D GO-encapsulated gold nanoparticle, is developed to induce the double enhancement effect of graphene oxide and gold nanoparticle on SERS signals which is only effective for undifferentiated NSCs. The Raman peaks achieved from undifferentiated NSCs on the graphene oxide (GO)-encapsulated gold nanoparticles were 3.5 times higher than peaks obtained from normal metal structures and were clearly distinguishable from those of differentiated cells. The number of CC bonds and the Raman intensity at 1656 cm(-1) was found to show a positive correlation, which matches the differentiation state of the NSCs. Moreover, the substrate composed of 3D GO-encapsulated gold nanoparticles was also effective at distinguishing the differentiation state of single NSC by using electrochemical and electrical techniques. Hence, the proposed technique can be used as a powerful non-destructive in situ monitoring tool for the identification of the differentiation potential of various kinds of stem cells (mesenchymal, hematopoietic, and neural stem cells).
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