Evidence map›Paper›PMID 23937859›Full record

ArticleClinical proteomics2013

Proteomic analysis of kidneys from selenoprotein M transgenic rats in response to increased bioability of selenium.

Jun Seo Goo, Yo Na Kim, Kyung Mi Choi, In Sik Hwang, Ji Eun Kim, Young Ju Lee, Moon Hwa Kwak, Sun Bo Shim, Seung Wan Jee, Chul Joo Lim and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical proteomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Selenocysteine-Mediated Expressed Protein Ligation of SELENOM.Methods in molecular biology (Clifton, N.J.) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Jun Seo Goo *Department of Biomaterials Science, College of Natural Resources & Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 627-706, South Korea.
Yo Na Kim *Laboratory of Developmental Biology and Genomics, College of Veterinary Medicine, BK21 Program for Veterinary Science, Seoul National University, Seoul 151-742, South Korea.
Kyung Mi ChoiLaboratory of Developmental Biology and Genomics, College of Veterinary Medicine, BK21 Program for Veterinary Science, Seoul National University, Seoul 151-742, South Korea.
In Sik HwangDepartment of Biomaterials Science, College of Natural Resources & Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 627-706, South Korea.
Ji Eun KimDepartment of Biomaterials Science, College of Natural Resources & Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 627-706, South Korea.
Young Ju LeeDepartment of Biomaterials Science, College of Natural Resources & Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 627-706, South Korea.
Moon Hwa KwakDepartment of Biomaterials Science, College of Natural Resources & Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 627-706, South Korea.
Sun Bo ShimDepartment of Laboratory Animal Resources, National Institute of Food and Drug Safety, Korea FDA, Osong 363-700, Korea.
Seung Wan JeeDepartment of Laboratory Animal Resources, National Institute of Food and Drug Safety, Korea FDA, Osong 363-700, Korea.
Chul Joo LimDepartment of Laboratory Animal Resources, National Institute of Food and Drug Safety, Korea FDA, Osong 363-700, Korea.
Je Kyung SeongLaboratory of Developmental Biology and Genomics, College of Veterinary Medicine, BK21 Program for Veterinary Science, Seoul National University, Seoul 151-742, South Korea.
Dae Youn HwangDepartment of Biomaterials Science, College of Natural Resources & Life Science, Life and Industry Convergence Research Institute, Pusan National University, Miryang 627-706, South Korea.
Pusan National University · KRNational Institute of Food and Drug Safety Evaluation · KRSeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo characterize changes in global protein expression in kidneys of transgenic rats overexpressing human selenoprotein M (SelM) in response to increased bioabivility of selenium (Sel), total proteins extracted from kidneys of 10-week-old CMV/hSelM Tg and wild-type rats were separated by 2-dimensional gel electrophoresis and measured for changes in expression.

resultsTen and three proteins showing high antioxidant enzymatic activity were up- and down-regulated, respectively, in SelM-overexpressing CMV/hSelM Tg rats compared to controls based on an arbitrary 2-fold difference. Up-regulated proteins included LAP3, BAIAP2L1, CRP2, CD73 antigen, PDGF D, KIAA143 homolog, PRPPS-AP2, ZFP313, HSP-60, and N-WASP, whereas down-regulated proteins included ALKDH3, rMCP-3, and STC-1. After Sel treatment, five of the up-regulated proteins were significantly increased in expression in wild-type rats, whereas there were no changes in CMV/hSelM Tg rats. Only two of the down-regulated proteins showed reduced expression in wild-type and Tg rats after Sel treatment.

conclusionsThese results show the primary novel biological evidences that new functional protein groups and individual proteins in kidneys of Tg rats relate to Sel biology including the response to Sel treatment and SelM expression.

Identifiers

PMID23937859
PMCPMC3751301
OpenAlexW2115139902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.