ArticleJournal of psychiatry & neuroscience : JPN2014
Abnormal interhemispheric connectivity in male psychopathic offenders.
Article in Journal of psychiatry & neuroscience : JPN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Transcranial magnetic stimulation in forensic populations: scoping review.Frontiers in psychology · 2026Pooled it
- Using physiological biomarkers in forensic psychiatry: a scoping review.Frontiers in psychiatry · 2025Pooled it
- Abnormal functional asymmetry and its behavioural correlates in adults with ADHD: A TMS-EEG study.PloS one · 2023Article
- Differential relations between juvenile psychopathic traits and resting state network connectivity.Human brain mapping · 2015Article
- Temporal dynamics of L5 dendrites in medial prefrontal cortex regulate integration versus coincidence detection of afferent inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Cerebral lateralization of pro- and anti-social tendencies.Experimental neurobiology · 2014Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundPsychopathic offenders inevitably violate interpersonal norms and frequently resort to aggressive and criminal behaviour. The affective and cognitive deficits underlying these behaviours have been linked to abnormalities in functional interhemispheric connectivity. However, direct neurophysiological evidence for dysfunctional connectivity in psychopathic offenders is lacking.
methodsWe used transcranial magnetic stimulation combined with electroencephalography to examine interhemispheric connectivity in the dorsolateral and motor cortex in a sample of psychopathic offenders and healthy controls. We also measured intracortical inhibition and facilitation over the left and right motor cortex to investigate the effects of local cortical processes on interhemispheric connectivity.
resultsWe enrolled 17 psychopathic offenders and 14 controls in our study. Global abnormalities in right to left functional connectivity were observed in psychopathic offenders compared with controls. Furthermore, in contrast to controls, psychopathic offenders showed increased intracortical inhibition in the right, but not the left, hemisphere. LIMITATIONS: The relatively small sample size limited the sensitivity to show that the abnormalities in interhemispheric connectivity were specifically related to the dorsolateral prefrontal cortex in psychopathic offenders.
conclusionTo our knowledge, this study provides the first neurophysiological evidence for abnormal interhemispheric connectivity in psychopathic offenders and may further our understanding of the disruptive antisocial behaviour of these offenders.
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